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DOI: 10.1055/s-2004-860983
Anaphylactic Shock: Pathophysiology, Recognition, and Treatment
Publication History
Publication Date:
22 December 2004 (online)
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ABSTRACT
Anaphylaxis is a systemic, type I hypersensitivity reaction that often has fatal consequences. Anaphylaxis has a variety of causes including foods, latex, drugs, and hymenoptera venom. Epinephrine given early is the most important intervention. Adjunctive treatments include fluid therapy, H1 and H2 histamine receptor antagonists, corticosteroids, and bronchodilators; however these do not substitute for epinephrine. Patients with a history of anaphylaxis should be educated about their condition, especially with respect to trigger avoidance and in the correct use of epinephrine autoinjector kits. Such kits should be available to the sensitized patient at all times.
KEYWORDS
Anaphylaxis - epinephrine - shock - allergy
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Roger F JohnsonM.D.
Center for Lung Research, T-1217 MCN, Vanderbilt University Medical Center
1161 21st Ave. South
Nashville, TN 37232-2650
Email: roger.johnson@vanderbilt.edu