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DOI: 10.1055/s-2006-951305
Free Carnitine Levels in Respiratory Distress Syndrome during the First Week of Life
Publication History
Publication Date:
28 September 2006 (online)
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ABSTRACT
Antenatal carnitine administration has been shown to induce fetal lung maturity by increasing pulmonary surfactant in animal and human studies. The aim of this study was to investigate serum free carnitine (FC) levels in preterm infants with respiratory distress syndrome (RDS) and controls during the first week of postnatal life. The study groups consisted of 76 preterm infants with gestational ages ranging from 28 to 36 weeks, and birthweights ranging from 1046 to 2352 g. Serum FC levels were measured in preterm infants (group A, 37 with RDS; group B, 39 controls without RDS) within the first 6 hours after birth, on days 3 and 7. For specific analyses, serum FC levels were determined for gestational ages 28 to 31 weeks and 32 to 36 weeks in both groups. Initial FC levels were decreased insignificantly in group A (22.5 ± 7.3 μmol/L) compared with group B (23.5 ± 6.8 μmol/L; p > 0.05). On days 3 and 7 of life, serum FC levels were significantly lower in group A (18.3 ± 6.1 and 10.2 ± 3.3 μmol/L, respectively) than in group B (23.4 ± 7.1 and 22.8 ± 3.7 μmol/L, respectively; p < 0.05 and p < 0.05, respectively) on days 3 and 7 of life, respectively. Serum FC level remained stable in the non-RDS group (p > 0.05), but it decreased significantly in the RDS group during the first week of postnatal life (p < 0.05). No differences were seen between the corresponding gestational age groups. Serum FC levels in RDS infants decreased from days 1 to 7. Decreased neonatal serum carnitine levels in preterm infants with RDS during the first week of life might be caused by increasing consumption of carnitine in lung tissue for surfactant synthesis.
KEYWORDS
Carnitine - respiratory distress syndrome - preterm - first week of life
REFERENCES
- 1 Arenas J, Rubio J C, Martin M A et al.. Biological roles of L-carnitine in perinatal metabolism. Early Hum Dev. 1998; 53 43-50
- 2 Arduini A, Zibellini G, Ferrari L et al.. Participation of carnitine palmitoyltransferase in the synthesis of dipalmitoylphosphatidylcholine in rat alveolar type II cells. Mol Cell Biochem. 2001; 218 81-86
- 3 Lohninger A, Bock P, Dadak C et al.. Effect of carnitine on foetal rat lung dipalmitoyl phosphatidylcholine content and lung morphology. Carnitine and lung surfactant, I. J Clin Chem Clin Biochem. 1990; 28 313-318
- 4 Lohninger A, Laschan C, Auer B et al.. Animal experiment and clinical studies of the significance of carnitine for energy metabolism in pregnant patients and the fetus during the pre- and perinatal period. Wien Klin Wochenschr. 1996; 108 33-39
- 5 Kurz C, Arbeiter K, Obermair A et al.. L-carnitine-betamethasone combination therapy versus betamethasone therapy alone in prevention of respiratory distress syndrome. Z Geburtshilfe Perinatol. 1993; 197 215-219
- 6 Lohninger A, Krieglsteiner H P, Hajos F et al.. Effects of prenatal treatment with betamethasone, L-carnitine or betamethasone-L-carnitine combinations on the phosphatidylcholine content and composition of the foetal and maternal rat lung. Eur J Clin Chem Clin Biochem. 1996; 34 387-391
- 7 Lohninger A, Krieglsteiner P, Nikiforov A et al.. Comparison of the effects of betamethasone and 1-carnitine on dipalmitoylphosphatidylcholine content and phosphatidylcholine species composition in fetal rat lungs. Pediatr Res. 1984; 18 1246-1252
- 8 Shihabi Z K, Oles K S, McCormick C P et al.. Serum and tissue carnitine assay based on dialysis. Clin Chem. 1992; 38 1414-1417
- 9 Meyburg J, Schulze A, Kohlmueller D et al.. Postnatal changes in neonatal acylcarnitine profile. Pediatr Res. 2001; 49 125-129
- 10 Meyburg J, Schulze A, Kohlmueller D et al.. Acylcarnitine profiles of preterm infants over the first four weeks of life. Pediatr Res. 2002; 52 720-723
- 11 Iafolla A K, Browning III I B, Roe C R. Familial infantile apnea and immature beta-oxidation. Pediatr Pulmonol. 1995; 20 167-171
- 12 Whitfield J, Smith T, Sollohub H et al.. Clinical effects of L-carnitine supplementation on apnea and growth in very low birthweight infants. Pediatrics. 2003; 111 477-482
- 13 Novak M, Monkus E F, Chung D et al.. Carnitine in the perinatal metabolism of lipids I: relationship between maternal and fetal plasma levels of carnitine and acylcarnitines. Pediatrics. 1981; 67 95-100
Esad KokluM.D.
Department of Pediatrics, Division of Neonatology, Erciyes University, School of Medicine
38039 Kayseri, Turkey