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Planta Med 1993; 59(4): 333-336
DOI: 10.1055/s-2006-959694
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© Georg Thieme Verlag Stuttgart · New York

Antidiarrhoeic Activity of Euphorbia hirta Extract and Isolation of an Active Flavonoid Constituent

J. Galvez, A. Zarzuelo, M. E. Crespo, M. D. Lorente, M. A. Ocete, J. Jiménez
  • Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, E-18071 Granada, Spain
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The antidiarrhoeic activity of the Euphorbia hirta whole plant was investigated. The lyo-philized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by castor oil, arachidonic acid, and prostaglandin E2. It showed no activity when magnesium sulphate was used to provoke the diarrhoea. The lyophilized decoction delayed small intestinal transit when this was accelerated by castor oil but not in normal conditions. A flavonoid, quercitrin, with antidiarrhoeic activity was isolated from this crude drug.

Key words

Euphorbia hirta - antidiarrhoeic activity - quercitrin