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Planta Med 1988; 54(5): 405-409
DOI: 10.1055/s-2006-962482
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© Georg Thieme Verlag Stuttgart · New York

Solubilization of Saponins of Bupleuri Radix with Ginseng Saponins: Cooperative Effect of Dammarane Saponins

Kazuhiro Watanabe, Hiroko Fujino, Toshinobu Morita, Ryoji Kasai, Osamu Tanaka
  • Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima 734 Japan.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

It has been found that the water solubilities of saikosaponins, the active principles of Bupleuri radix, are greatly increased in the presence of ginsenoside-Ro, the glucuronide bisdesmoside of oleanolic acid of Ginseng. No solubilizing effect was observed with the neutral dammarane Saponins of Ginseng. However, the solubilizing effect of ginsenoside-Ro was significantly potentiated in the presence of the dammarane saponins of 20 (S)-protopanaxadiol. The relationship between the solubilizing effect and the structure of ginsenoside-Ro was also investigated, elucidating the important role of the glucuronide moiety.