Planta Med 1988; 54(6): 506-510
DOI: 10.1055/s-2006-962531
Papers

© Georg Thieme Verlag Stuttgart · New York

Tigliane-Type Diterpene Esters from Synadenium grantii 1,5

R. Bagavathi2 , B. Sorg3 , E. Hecker3
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  • 3German Cancer Research Center, Institute of Biochemistry, Im Neuenheimer Feld 280, D-6900 Heidelberg, Federal Republic of Germany.
1 Part XIV in the series ‘Skin Irritant Principles of Euphorbiaceae’, for part XIII see: Ref.(1).5 Dedicated to Prof. Dr. H. Schildknecht, Institute of Organic Chemistry, University of Heidelberg on occasion of his 65th birthday in appreciation of his many fascinating contributions to natural product chemistry.
Further Information

Publication History

1987

Publication Date:
24 January 2007 (online)

Abstract

From the latex of Synadenium grantii Hook F. (Euphorbiaceae) were isolated by chromatographic methods five diterpene 12,13-diesters of the tigliane-type parent alcohols 4-deoxyphorbol (1a), 4,20-dideoxy-5α-hydroxyphorbol (2a) and 20-deoxy-5α-hydroxyphorbol (3a) with isobutyric, tiglic and phenylacetic acid. Of these, 4-deoxyphorbol-13-(phenylacetate)-12-tiglate (1f) turned out to be highly irritant on the mouse ear while the rest of the esters had rather low or no irritant activity; 1f was also assayed for tumor-promoting activity and proved to be almost inactive.