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Horm Metab Res 1990; 22(3): 188-191
DOI: 10.1055/s-2007-1004880
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Effect of Adrenergic Agonists on Human Chorionic Gonadotropin Release by Human Trophoblast Cells Obtained from First Trimester Placenta

N. Oike1 , M. Iwashita2 , T. Muraki1 , T. Nomoto1 , Y. Takeda3 , S. Sakamoto2
  • 1Department of Pharmacology, Tokyo Women's Medical College, Kawadacho, Shinjuku-ku, Tokyo, Japan
  • 2The Maternal and Perinatal Center, Tokyo Women's Medical College, Kawadacho, Shinjuku-ku, Tokyo, Japan
  • 3Department of Gynecology and Obstetrics, Tokyo Women's Medical College, Kawadacho, Shinjuku-ku, Tokyo, Japan
Further Information

Publication History

1989

1989

Publication Date:
14 March 2008 (online)

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Summary

The cultured syncytiotrophoblast cells from human first trimester placenta were used to determine the effect of adrenergic agonists on human chorionic gonadotropin (hCG) production in vitro. Beta-adrenergic agonists isoproterenol, ritodrine and isoxsuprine increased the hCG release during the 2 h incubation period, however, alpha-agonists norepinephrine and phenylephrine and a beta1-agonist dobutamine had no effect. The effect of isoproterenol was blocked by propranolol and butoxamine, but less efficiently by phentolamine and atenolol. These results indicate that placental hCG production can be modulated by stimulation of beta-, possibly beta2-adrenoceptors but not by alpha-adrenoceptors.

Key words

Human Chorionic Gonadotropin - Cultured Placental Cells - Beta2-Adrenoceptor - Ritodrine