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Horm Metab Res 1989; 21(4): 179-181
DOI: 10.1055/s-2007-1009185
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© Georg Thieme Verlag, Stuttgart · New York

Central Adrenoceptors and Basal Prolactin Release in the Rat

E. J. de Castro e Silva1 , J. Antunes-Rodrigues2
  • 1Departamento de Fisiologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brasil
  • 2Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brasil
Further Information

Publication History

1987

1988

Publication Date:
14 March 2008 (online)

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Summary

The influence of the central adrenergic system on basal prolactin secretion was investigated in the rat. Several selective adrenoceptor blockers were centrally administered and their effects on prolactin secretion were observed. Blockade of beta-1 receptors by practolol, beta-2 receptors by IPS 339 and alpha-2 receptors by DG-5128 did not modify basal prolactin secretion, but alpha-1 adenoceptor blockade by prazosin strongly enhanced prolactin plasma levels. These findings suggest that noradrenergic pathways in the central nervous system exert inhibitory tone on basal prolactin secretion, and that this effect seems to be mediated by alpha-1 adrenoceptors.

Key-Words

Prolactin - Central Adrenoceptors - Adrenergic Blockers