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Horm Metab Res 1985; 17(10): 522-527
DOI: 10.1055/s-2007-1013594
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Gigantism Associated with McCune-Albright's Syndrome

H. Nakagawa, A. Nagasaka, T. Sugiura1 , K. Nakagawa1 , Y. Yabe1 , N. Nihei2 , M. Hirooka2 , M. Itoh3 , A. Nakai, T. Ohyama, T. Aono, J. E. Gerich3
  • Department of Internal Medicine, Fujita-Gakuen University School of Medicine, Toyoake, Aichi, Japan
  • 1Department of Orthopedics, Fujita-Gakuen University School of Medicine, Toyoake, Aichi, Japan
  • 2Department of Internal Medicine, Hamamatsu University, School of Medicine, Hamamatsu, Shizuoka, Japan
  • 3Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, U.S.A.
Further Information

Publication History

1983

1984

Publication Date:
14 March 2008 (online)

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Summary

The case of a 16 year-old boy with McCune-Albright's syndrome which is rarely accompanied by gigantism was studied endocrinologically.

The stimulation of growth hormone (GH) release by hypoglycemia, the decline of elevated GH by hyperglycemia and a little lower somatostatin like immunoreactivity (SLI) may support abnormalities of hypothalamic function, but the existence of pituitary microadenoma cannot be ruled out because of the paradoxical suppression of GH release by oral administration of bromocriptine (CB-154) and L-DOPA and the stimulation of GH release by intravenous administration of TRH.

Key-Words:

Gigantism - McCune-Albright's Syndrome

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