Inhibition of Cholesterol Biosynthesis by BM 15.766

Summary

BM 15.766 (4-[2-[1-(4-chlorocinnamyl)piperazin-4-yl]ethyl]benzoic acid) showed a dose dependent action on ¹⁴C-acetate incorporation in cholesterol and intermediates including squalene by adult rat hepatocytes in primary monolayer culture. The biosynthesis of cholesterol could be reduced by more than 90%. Simultaneously, the 7-dehydrocholesterol level rose in the cells and, to a less marked extent, in the culture medium.