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Horm Metab Res 1995; 27(2): 79-82
DOI: 10.1055/s-2007-979913
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© Georg Thieme Verlag Stuttgart · New York

The Influence of Prostaglandins, Cyclooxygenase and Lipoxygenase Inhibitors on Collagen Concentration in the Rat Uterine Cervix

A. Bieńkiewicz
  • Institute of Obstetrics and Gynecology and Department of Pathophysiology, Medical University of Łódź, Łódź, Poland
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Publication History

1994

1994

Publication Date:
23 April 2007 (online)

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Abstract

The biochemical changes in the pregnant cervix near term after prostaglandin administration are still not well known. We investigated PGF2α and PGE2 induced changes in collagen concentration in late pregnant rat cervix. The influence of cyclooxygenase and dual cyclo- and 5-lipoxygenase inhibitors on collagen concentration in late pregnant rat cervix was also evaluated. Total collagen and its soluble fraction were measured in a population of 58 pregnant rats; treated with PGF2α (n = 16), PGE2 (n = 11), Diclofenac (cyclooxygenase inhibitor) (n = 11), BW 755C (dual inhibitor of cyclooxygenase and lipoxygenase) (n = 7) and controls (n = 13). The results of the study suggest that cervical collagen concentration is controlled at least in part by prostaglandins and leukotrienes.

Key words

Cervix - Rat - Prostaglandins - Diclofenac - BW 755C - Collagen

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