Oscillatory effects in a homeopathic clinical trial: an explanation using complexity theory, and implications for clinical practice

Abstract

Four double-blind, randomised, placebo-controlled clinical trials of asthma or rhinitis treated with homeopathic immunotherapy (HIT) at a 30C potency have been published. The most recent study, involving house dust mite allergic asthmatics, failed to confirm a therapeutic improvement at the end of the study, but did provide preliminary evidence for an oscillation in outcome (both physiological and subjective) in with verum treatment to placebo. In this paper we show how such an oscillation is consistent with a complexity theory interpretation of how the body functions as a whole, and speculate on why different studies have produced different results. If the complexity theory interpretation is correct, then this will have a significant impact on the design of clinical trials in homeopathy and, possibly, other complementary medical interventions.

Keywords

isopathy - homeopathic immunotherapy - asthma - oscillation - aggravation - complexity - networks

• References

• 1 Lewith GT, Watkins AD, Hyland ME, Shaw S, Broomfield J, Dolan G, Holgate ST. A double-blind, randomised, controlled clinical trial of ultramolecular potencies of house dust mite in asthmatic patients. BMJ 2002; 324: 520-523.
• 2 Reilly DT, Taylor MA, McSharry C, Aitchison T. Is homoeopathy a placebo response? Controlled trial of homoeopathic potency, with pollen in hayfever as model. Lancet 1986; 2: 881-886.
• 3 Reilly D, Taylor MA, Beattie N GM, Campbell JH, McSharry C, Aitchison TC, Carter R, Stevenson RD. Is evidence for homoeopathy reproducible?. Lancet 1994; 344: 1601-1606.
• 4 Taylor MA, Reilly D, Llewellyn-Jones RH, McSharry C, Aitchison TC. Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series. BMJ 2000; 321: 471-476.
• 5 Hyland ME. The intelligent body. New Scientist 2001; 170: 32-33.
• 6 Hyland ME. The intelligent body and its discontents. J Health Psychol 2002; 7: 21-32.
• 7 Hyland ME. A two-phase network theory of atopy and asthma causation: a possible solution to the impact of genes, hygiene and air quality. Clin Exp Allergy 2001; 31: 1485-1492.
• 8 Torres, J, L, Homeopathic effect: a network perspective, Br Hom J.
• 9 Bellavite P, Lussignoli S, Semizzi ML, Ortolani R, Signorini A. The similia principle: from cellular models to regulation of homeostasis. Br Hom J 1997; 86: 73-85.
• 10 Bellavite P, Semizzi M, Lussignoli S, Andrioli G, Bartocci U. A computer model of the ‘five elements’ theory of traditional Chinese medicine. Compl Ther Med 1998; 6: 133-140.