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Zeitschrift für Phytotherapie 2018; 39(04): 152-158
DOI: 10.1055/a-0636-1977
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© Georg Thieme Verlag KG Stuttgart · New York

Arabinogalaktan-Proteine (AGPs) aus dem kurzzeiterhitzten Presssaft von Echinacea purpurea

Arabinogalactan-proteins from short-term heat treated pressed juice of Echinacea purpurea
Birgit Classen
Pharmazeutisches Institut der Universität Kiel
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Further Information

Publication History

Eingereicht 17 May 2018

Revision akzeptiert 31 July 2018

Publication Date:
04 September 2018 (online)

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Zusammenfassung

Presssäfte der oberirdischen Teile von Echinacea purpurea (L.) Moench werden als unspezifische Immunstimulanzien eingesetzt. Als potenzielle Wirkstoffe werden hoch molekulare Polysaccharide bzw. Glykoproteine, insbesondere Arabinogalaktan-Proteine (AGPs), diskutiert. Aus dem kurzzeiterhitzten Presssaft von Echinacea purpurea wurde daher eine hochmolekulare Arabinogalaktan-Protein-Fraktion durch spezifische Fällung mit Yariv‘s Reagenz isoliert und charakterisiert. Es konnte gezeigt werden, dass die Hauptstrukturelemente des Polysaccharidanteils der AGPs denen des unbehandelten Presssaftes entsprechen und dass der AGP-Gehalt im Vergleich zu Ethanol-stabilisierten Presssäften um ein Vielfaches erhöht ist. Für Arabinogalaktan-Proteine aus den oberirdischen Teilen des Roten Sonnenhuts konnten in vitro bereits verschiedene immunmodulierende Aktivitäten nachgewiesen werden.

Abstract

Pressed juices of the aerial parts of Echinacea purpurea (L.) Moench are used as unspecific immunostimulants. Putative active compounds may be high-molecular-weight polysaccharides and / or glycoproteins, especially arabinogalactan-proteins (AGPs). From a heat treated pressed juice of Echinacea purpurea, a high-molecular-weight AGP fraction was isolated by specific precipitation with Yariv’s reagent and characterized. It could be shown, that main structural elements of the polysaccharide part of AGPs resemble those of the untreated pressed juice and that the content of AGPs is many times higher compared to ethanol treated pressed juices. For AGPs from aerial parts of purple coneflower, different immunomodulating activities have already been shown in vitro.

Schlüsselwörter

Echinacea purpurea (L.) Moench - Presssaft - Kurzzeiterhitzung - Arabinogalaktan-Protein - Immunmodulation

Keywords

Echinacea purpurea (L.) Moench - pressed juice - short-term heat treatment - arabinogalactan-protein - immunomodulation
 

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