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Drug Res (Stuttg) 2019; 69(08): 419-427
DOI: 10.1055/a-0850-6518
Review
© Georg Thieme Verlag KG Stuttgart · New York

Caveolins; An Assailant or An Ally of Various Cellular Disorders

Ritesh Kumar Srivastav
1   Faculty of Pharmacy, Kamla Nehru Institute of Management and Technology, Sultanpur, India
,
Tarique Mahmood Ansari
2   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Mahesh Prasad
1   Faculty of Pharmacy, Kamla Nehru Institute of Management and Technology, Sultanpur, India
,
Vishal Kumar Vishwakarma
3   Department of Pharmacology, R.R.S College of Pharmacy, Amethi, Uttar Pradesh, India
,
Paramdeep Bagga
2   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Farogh Ahsan
2   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

received 01 January 2019

accepted 01 February 2019

Publication Date:
18 February 2019 (online)

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Abstract

Caveolae have impressive morphological highlights of the cytomembrane of mammalian cells which involve in wide diversity of cellular functions involving signaling pathways and cholesterol hastening. Caveolin proteins possess a ‘scaffolding’ domain which for caveolin-1 and caveolin-3 appear to act a dominant role in signal regulation through caveolae. Caveolin-1 is treated to be protein in the cytomembrane entrapped with caveolae in endothelial cells and vascular smooth muscle cells which diminish nitric oxide (NO) by fill up the calcium/calmodulin (Ca2+/CaM) confining point of endothelial nitric oxide synthase (eNOS), decrease NO generation produce endothelial dysfunction and atherosclerotic injury development. It is a cholesterol-binding layer protein associated with cell cholesterol transport and also shows cardioprotective action through ischemic preconditioning (IPC) in diabetic and postmenopausal rat heart. Additionally it is ensnared in the procedures of tumorigenesis, prostate disease, and inflammation. The present study in the paper is to explore the structural functionalities of caveolins and their contributory role in CVS disorders and various other diseases.

Key words

caveolins - cardiovascular disorder - diabetic - ischaemic preconditioning - nitric oxide - cell growth
 

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