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Synlett 2021; 32(08): 814-816
DOI: 10.1055/a-1384-0159
letter

Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides

Connor J. O’Brien
,
David A. Nicewicz  ∗
National Institute of General Medical Sciences (R35 GM136330)
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Abstract

The use of carbon dioxide as a C1 chemical feedstock remains an active field of research. Here we showcase the use of milled dry ice as a method to promote the availability of CO2 in a reaction solution, permitting practical synthesis of arylcarboxylic acids. Notably, the use of milled dry ice produces marked increases in yields relative to those obtained with gaseous CO2, as previously reported in the literature.

Key words

carboxylation - carbon dioxide - C1 source - dry ice - arylcarboxylic acids

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-1384-0159.
  • Supporting Information


Publication History

Received: 18 December 2020

Accepted after revision: 04 February 2021

Accepted Manuscript online:
04 February 2021

Article published online:
19 February 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
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