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Synthesis 2021; 53(19): 3522-3534
DOI: 10.1055/a-1486-2158
DOI: 10.1055/a-1486-2158
short review
Recent Advances in the Tandem Difunctionalization of Alkynes: Mechanism-Based Classification
We thank the Natural Science Foundation of Zhejiang Province (LQ18B020001) and the Foundation of University Student Innovation Program for financial support.
Abstract
Recent advances on the tandem difunctionalization of alkynes in the last decade (2010–2020) are summarized into five categories based on the type of mechanism: (1) radical addition and coupling for the synthesis of polysubstituted ketones and alkenes, (2) electrophilic addition of alkynes, (3) reactions mediated by haloalkynes or copper acetylides, (4) the preparation of cyclic compounds via radical processes, palladium-catalyzed reactions or conjugate additions, and (5) cyclic compounds as intermediates in ring openings. Herein, radical, electrophilic and nucleophilic reactions are discussed in detail. We hope this review will help to promote future research in this area.
1 Introduction
2 Radical Addition and Coupling
3 Electrophilic Addition
4 Reactions Mediated by Haloalkynes or Copper Acetylides
5 Cyclization
6 Cyclization and Ring Opening
7 Conclusions
Publication History
Received: 23 March 2021
Accepted after revision: 19 April 2021
Accepted Manuscript online:
19 April 2021
Article published online:
19 May 2021
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