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DOI: 10.1055/a-1516-2471
State of the Art: Therapie mit Statinen
State of the Art: Statin Therapy
Im Jahr 2020 wurden hierzulande 2,7 Milliarden Statin-Tabletten verordnet, das entspricht bei täglicher Einnahme 7,6 Millionen Menschen in Deutschland [1]. Daher hat jeder Internist oder Allgemeinmediziner täglich mit Statin-Verschreibungen zu tun. Die vorliegende Übersichtsarbeit fasst die aktuelle Datenlage zur klinischen Pharmakologie und Wirksamkeit sowie zu Nebenwirkungen und speziellen Therapie-Situationen zusammen.
Abstract
This review summarizes the pharmacology and clinical use of HMG-CoA reductase inhibitors, statins. LDL-Cholesterol lowering with statins reduces atherosclerotic cardiovascular risk by approx. one quater per year of treatment. The efficacy and safety of statins are demonstrated by randomized trials irrespective of the patient’s age. The synthetic statins, rosuvastatin and atorvastatin, are superior with regard to LDL-C lowering, half-life and drug-interactions compared to the older statins such as simvastatin. Modern lipid lowering therapy uses individualized statin-based combination therapies.
Schlüsselwörter
Statine - HMG-CoA-Reduktase - Pharmakologie - pleiotrope Effekte - Statin-IntoleranzPublication History
Article published online:
06 December 2021
© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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