Glaucoma following Infant Lensectomy: 2021 Update

Abstract

Purpose To review information pertaining to glaucoma following infant lensectomy surgery and to provide evidence to support the responsible mechanism of this condition.

Methods and Results Described risk factors and proposed mechanisms for infantile aphakic glaucoma were assessed. The clinical evidence observed in affected glaucoma patients was analyzed, and evidence of postoperative anterior chamber fibrosis was reviewed and interpreted.

Conclusion The review and assessment of laboratory and clinical evidence support the proposal that infantile aphakic glaucoma is caused, in part, by postoperative anterior chamber fibroization related to lens cell dispersion and active epithelial-mesenchymal transition with resultant filtration angle tissue injury and loss of function.

Zusammenfassung

Ziel Ziel dieser Studie war es, Informationen über das Auftreten eines Glaukoms nach einer im frühkindlichen Alter durchgeführten Lensektomie zu überprüfen und Beweise für den dafür verantwortlichen Mechanismus zu liefern.

Methoden und Ergebnisse Beschriebene Risikofaktoren und vermutete Mechanismen des infantilen aphakischen Glaukoms wurden evaluiert. Es wurden die in Glaukompatienten beobachteten klinischen Befunde analysiert, und die Hinweise auf eine postoperative Fibrose der vorderen Augenkammer wurden überprüft und interpretiert.

Schlussfolgerung Die Überprüfung und Evaluierung von Laborwerten und klinischen Beweisen stützen die Hypothese, dass das infantile aphakische Glaukom zum Teil durch eine postoperative Fibrosierung der vorderen Augenkammer verursacht wird, die im Zusammenhang mit der Dispersion der Linsenzellen und der aktiven epithelial-mesenchymalen Transition steht, die zu einer Schädigung des Filtrationswinkels mit Funktionsverlust führt.

Key words

congenital cataract - infant lensectomy - glaucoma - fibroization - EMT

Schlüsselwörter

angeborene Linsentrübung - Lensektomie im Kleinkindalter - Glaukom - Fibrosierung - EMT

Publication History

Received: 17 May 2021

Accepted: 15 July 2021

Article published online:
17 September 2021

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