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Horm Metab Res 2022; 54(03): 162-167
DOI: 10.1055/a-1756-4937
Endocrine Care

Application of Metanephrine and Normetanephrine in Evaluating the Selectivity of Adrenal Vein Sampling

Wei Liu
1   National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China
,
Jingjing Zhang
1   National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China
,
Yaling Yang
2   Department of Metabolism and Endocrinology, Xuhui Central Hospital, Fudan University, Shanghai, China
,
Yinxin Jin
1   National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China
,
Zaizhao Li
1   National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China
,
Liting You
1   National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China
,
Jianguang Luo
3   Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
,
Xin Su 
1   National Clinical Research Center for Metabolic Diseases, Institute of Metabolism and Endocrinology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Hunan, China
› Author Affiliations Financial support This study was supported by the Hunan Provincial Science and Technology Department (2017sk2022, 2020JJ4806, 2020JJ5816).
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Abstract

The aim of the study was to investigate the usefulness of metanephrine (MN) and normetanephrine (NMN) in bilateral simultaneous adrenal vein sampling (AVS) with and without ACTH stimulation. The study was conducted in a single referral center. Prospective recruited patients with PA were treated with AVS. The effects of cortisol, MN and NMN on selectivity catheterization were assessed and determined by lateralization. We enrolled 54 patients with PA who were treated with simultaneous bilateral AVS with ACTH. The Selectivity Index (SI) calculated by MN was higher than that calculated by other indicators (p<0.001), the catheterization success rate of MN at baseline was the same as that of cortisol after ACTH stimulation, and in lateralization diagnosis, MN was not inferior to cortisol. In conclusion, among the studied indicators, MN is the best index for determining the catheterization selectivity in AVS, especially in the absence of ACTH stimulation.

Key words

metanephrine - normetanephrine - adrenal vein sampling - selectivity index

Supplementary Material



Publication History

Received: 15 November 2021

Accepted after revision: 26 January 2022

Article published online:
11 March 2022

© 2022. Thieme. All rights reserved.

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