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Synthesis 2022; 54(19): 4353-4360
DOI: 10.1055/a-1838-9491
DOI: 10.1055/a-1838-9491
paper
Iodine-Promoted N-Acylation of Amines with Hydrazide: An Efficient Metal-Free Amidation
We are grateful for financial support from the National Natural Science Foundation of China (Grant No. 21961038).
Abstract
An efficient protocol for the amidation of hydrazide with amine has been developed by utilizing I2 as an oxidant under metal- and base-free conditions at room temperature. N-Acylation products of amines were obtained in good to excellent yields without using toxic reagents. This method is operationally straightforward and tolerates aliphatic/aromatic and primary/secondary amines with different hydrazides.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1838-9491.
- Supporting Information
Publication History
Received: 10 March 2022
Accepted after revision: 28 April 2022
Accepted Manuscript online:
28 April 2022
Article published online:
08 June 2022
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