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Synthesis 2023; 55(05): 755-764
DOI: 10.1055/a-1948-2677
DOI: 10.1055/a-1948-2677
paper
A New Avenue to One-Pot Four-Component Synthesis of Spiro[indoline-3,4′-quinoline] Derivatives Using DABCO as a Green Catalyst
The authors are thankful for the financial support provided by IIT (BHU) in the form of TA (teaching assistantship).
Abstract
A simple, efficient, and green, one-pot four-component synthesis of spiro[indoline-3,4′-quinoline] derivatives has been developed from isatin, ethyl cyanoacetate/malononitrile, dimedone, and aniline using green catalyst DABCO and green solvent ethanol. The current method generates good to exceptional yields in a short reaction time and provides a broad substrate scope. This method also works for gram-scale reactions.
Keywords
DABCO - spiro[indoline-3,4′-quinoline] derivatives - isatin - ethyl cyanoacetate - malononitrile - dimedone - anilinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1948-2677.
- Supporting Information
Publication History
Received: 09 July 2022
Accepted after revision: 21 September 2022
Accepted Manuscript online:
21 September 2022
Article published online:
17 November 2022
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