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Klin Monbl Augenheilkd 2023; 240(09): 1052-1059
DOI: 10.1055/a-2105-1064
Übersicht

Altersbedingte Makuladegeneration in einer alternden Gesellschaft – aktuelle epidemiologische Forschungsansätze und Erkenntnisse

Article in several languages: deutsch | English
Caroline Brandl 
1   Universitäts-Augenklinik Regensburg, Universität Regensburg, Fakultät für Medizin, Deutschland
2   Lehrstuhl für Genetische Epidemiologie, Universität Regensburg, Fakultät für Medizin, Deutschland
,
Robert Patrick Finger
3   Universitäts-Augenklinik, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Ruprecht-Karls-Universität Heidelberg, Mannheim, Deutschland
4   Universitäts-Augenklinik Bonn, Universität Bonn, Deutschland
,
Iris Maria Heid
2   Lehrstuhl für Genetische Epidemiologie, Universität Regensburg, Fakultät für Medizin, Deutschland
,
Matthias Marten Mauschitz
4   Universitäts-Augenklinik Bonn, Universität Bonn, Deutschland
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Zusammenfassung

Epidemiologische Studien zur altersbedingten Makuladegeneration (AMD) liefern zentrale Daten zu den Häufigkeiten der Früh- bzw. Spätformen sowie zu assoziierten Risikofaktoren. Durch die stetig steigende Anzahl an populationsbasierten Querschnittstudien sowie longitudinalen Kohortenstudien in Deutschland und Europa mit publizierten Daten werden die Schätzer zur Prävalenz bzw. Inzidenz der AMD immer robuster. Sie zeigen allerdings, großenteils methodisch bedingte, Schwankungen. In der vorliegenden Übersichtsarbeit werden die aktuellsten publizierten epidemiologischen Maßzahlen zur AMD aus Deutschland und Zentral- bzw. Westeuropa zusammengetragen. Basierend auf diesen Daten sowie den Bevölkerungszahlen für Deutschland und Europa erfolgt eine Hochrechnung sowie Zukunftsprognose der Prävalenz. Die epidemiologische Evidenz zu AMD-assoziierten Risikofaktoren wird ebenfalls verbessert, vor allem durch Metaanalysen im Rahmen großer Konsortien mit entsprechend hohen Fallzahlen. Dieser Übersichtsartikel fasst neuste Erkenntnisse und daraus ableitbare Verhaltensempfehlungen als Präventionsansätze zusammen. Außerdem wird auf Therapieoptionen und zukünftige Herausforderungen eingegangen.

Schlüsselwörter

altersbedingte Makuladegeneration (AMD) - Prävalenz - Inzidenz - Risikofaktoren - populationsbasierte Studien - Bevölkerungsentwicklung


Publication History

Received: 26 April 2023

Accepted: 22 May 2023

Article published online:
04 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References/Literatur

  • 1 Lim LS, Mitchell P, Seddon JM. et al. Age-related macular degeneration. Lancet 2012; 379: 1728-1738
    CrossrefPubMedSearch in Google Scholar
  • 2 Klein R, Meuer SM, Myers CE. et al. Harmonizing the classification of age-related macular degeneration in the three-continent AMD consortium. Ophthalmic Epidemiol 2014; 21: 14-23
    CrossrefPubMedSearch in Google Scholar
  • 3 Buitendijk GHS, Rochtchina E, Myers C. et al. Prediction of age-related macular degeneration in the general population: The three continent AMD consortium. Ophthalmology 2013; 120: 2644-2655
    CrossrefPubMedSearch in Google Scholar
  • 4 Korb CA, Kottler UB, Wolfram C. et al. Prevalence of age-related macular degeneration in a large European cohort: results from the population-based Gutenberg Health Study. Graefes Arch Clin Exp Ophthalmol 2014; 252: 1403-1411
    CrossrefPubMedSearch in Google Scholar
  • 5 Lüdtke L, Jürgens C, Ittermann T. et al. Age-Related Macular Degeneration and Associated Risk Factors in the Population-Based Study of Health in Pomerania (SHIP-Trend). Med Sci Monit 2019; 25: 6383
    CrossrefPubMedSearch in Google Scholar
  • 6 Brandl C, Breinlich V, Stark KJ. et al. Features of Age-Related Macular Degeneration in the General Adults and Their Dependency on Age, Sex, and Smoking: Results from the German KORA Study. PLoS One 2016; 11: e0167181
    CrossrefPubMedSearch in Google Scholar
  • 7 Brandl C, Zimmermann ME, Gunther F. et al. On the impact of different approaches to classify age-related macular degeneration: Results from the German AugUR study. Sci Rep 2018; 8: 1-10
    CrossrefPubMedSearch in Google Scholar
  • 8 Li JQ, Welchowski T, Schmid M. et al. Prevalence and incidence of age-related macular degeneration in Europe: A systematic review and meta-analysis. Br J Ophthalmol 2020; 104: 1077-1084
    CrossrefPubMedSearch in Google Scholar
  • 9 Korb CA, Elbaz H, Schuster AK. et al. Five-year cumulative incidence and progression of age-related macular degeneration: results from the German population-based Gutenberg Health Study (GHS). Graefes Arch Clin Exp Ophthalmol 2022; 260: 55-64
    CrossrefPubMedSearch in Google Scholar
  • 10 Brandl C, Günther F, Zimmermann ME. et al. Incidence, progression and risk factors of age-related macular degeneration in 35–95-year-old individuals from three jointly designed German cohort studies. BMJ Open Ophthalmol 2022; 7: e000912
    CrossrefPubMedSearch in Google Scholar
  • 11 Davis MD, Gangnon RE, Lee LY. et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol 2005; 123: 1484-1498
    CrossrefPubMedSearch in Google Scholar
  • 12 Klein R, Davis MD, Magli YL. et al. The Wisconsin age-related maculopathy grading system. Ophthalmology 1991; 98: 1128-1134
    CrossrefPubMedSearch in Google Scholar
  • 13 Ferris FL, Davis MD, Clemons TE. et al. A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch Ophthalmol 2005; 123: 1570-1574
    CrossrefPubMedSearch in Google Scholar
  • 14 Ferris FL3rd Wilkinson CP, Bird A. et al. Clinical classification of age-related macular degeneration. Ophthalmology 2013; 120: 844-851
    CrossrefPubMedSearch in Google Scholar
  • 15 Grassmann F, Mengelkamp J, Brandl C. et al. A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography. Ophthalmology 2018; 125: 1410-1420
    CrossrefPubMedSearch in Google Scholar
  • 16 Garzone D, Terheyden JH, Morelle O. et al. Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report. Sci Rep 2022; 12: 21911
    CrossrefPubMedSearch in Google Scholar
  • 17 Gattoussi S, Buitendijk GHS, Peto T. et al. The European Eye Epidemiology spectral-domain optical coherence tomography classification of macular diseases for epidemiological studies. Acta Ophthalmol 2019; 97: 364-371
    CrossrefPubMedSearch in Google Scholar
  • 18 Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE). Rheinland-Studie. Im Internet (Stand: 16.05.2023): https://www.rheinland-studie.de/
    PubMed
  • 19 German National Cohort (GNC) Consortium. The German National Cohort: aims, study design and organization. Eur J Epidemiol 2014; 29: 371-382
    Search in Google Scholar
  • 20 Statistisches Bundesamt. Vorausberechneter Bevölkerungsstand. 2022. Im Internet (Stand: 16.05.2023): https://www-genesis.destatis.de/genesis/online?operation=ergebnistabelleUmfang&levelindex=2&levelid=1681828897390&downloadname=12421-0002%23abreadcrumb
    PubMed
  • 21 Gesundheitsberichterstattung des Bundes. Bevölkerung in 1000 (Prognose) nach der 15. koordinierten Bevölkerungsvorausberechnung. Gliederungsmerkmale: Jahre, Deutschland, Alter, Variante Bevölkerungsprognose. Im Internet (Stand: 16.05.2023): https://www.gbe-bund.de/gbe/pkg_isgbe5.prc_menu_olap?p_uid=gast&p_aid=65519721&%20p_sprache=D&%20p_help=4&%20p_indnr=716&%20p_indsp=&%20p_ityp=H
    PubMed
  • 22 Fritsche LG, Igl W, Bailey JNC. et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet 2016; 48: 134-143
    CrossrefPubMedSearch in Google Scholar
  • 23 Holliday EG, Smith AV, Cornes BK. et al. Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One 2013; 8: e53830
    CrossrefPubMedSearch in Google Scholar
  • 24 Winkler TW, Grassmann F, Brandl C. et al. Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease. BMC Med Genomics 2020; 13: 120
    CrossrefPubMedSearch in Google Scholar
  • 25 Velilla S, Garcia-Medina JJ, Garcia-Layana A. et al. Smoking and age-related macular degeneration: review and update. J Ophthalmol 2013; 2013: 895147
    CrossrefPubMedSearch in Google Scholar
  • 26 Milton RC, Clemons TE, Klien R. et al. Risk factors for the incidence of advanced age-related macular degeneration in the Age-Related Eye Disease Study (AREDS): AREDS report no. 19. Ophthalmology 2005; 112: 533-539.e1
    CrossrefPubMedSearch in Google Scholar
  • 27 Klein R, Myers CE, Buitendijk GH. et al. Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium. Am J Ophthalmol 2014; 158: 513-524.e3
    CrossrefPubMedSearch in Google Scholar
  • 28 Erke MG, Bertelsen G, Peto T. et al. Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study. Acta Ophthalmol 2014; 92: 662-669
    CrossrefPubMedSearch in Google Scholar
  • 29 Mauschitz MM, Schmitz MT, Verzijden T. et al. Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study. Am J Ophthalmol 2022; 236: 99-106
    CrossrefPubMedSearch in Google Scholar
  • 30 Merle BMJ, Cougnard-Grégoire A, Delyfer MN. et al. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium. Ophthalmology 2019; 126: 381-390
    CrossrefPubMedSearch in Google Scholar
  • 31 Stahl A. Diagnostik und Therapie der altersabhängigen Makuladegeneration. Dtsch Arztebl Int 2020; 117: 513-520
    CrossrefPubMedSearch in Google Scholar
  • 32 Blitzer AL, Ham SA, Colby KA. et al. Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study. JAMA Ophthalmol 2021; 139: 302-309
    CrossrefPubMedSearch in Google Scholar
  • 33 Mauschitz MM, Verzijden T, Schuster AK. et al. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans. Br J Ophthalmol 2022;
    CrossrefPubMedSearch in Google Scholar
  • 34 Romdhoniyyah DF, Harding SP, Cheyne CP. et al. Metformin, A Potential Role in Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. Ophthalmol Ther 2021; 10: 245-260
    CrossrefPubMedSearch in Google Scholar
  • 35 Spaide RF, Ooto S, Curcio CA. Subretinal drusenoid deposits AKA pseudodrusen. Surv Ophthalmol 2018; 63: 782-815
    CrossrefPubMedSearch in Google Scholar
  • 36 Ajana S, Cougnard-Grégoire A, Colijn JM. et al. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning. Ophthalmology 2021; 128: 587-597
    CrossrefPubMedSearch in Google Scholar
  • 37 Wecker T, Grundel B, Reichl S. et al. Anti-VEGF injection frequency correlates with visual acuity outcomes in pro re nata neovascular AMD treatment. Sci Rep 2019; 9: 3301
    CrossrefPubMedSearch in Google Scholar
  • 38 Holz FG, Tadayoni R, Beatty S. et al. Key drivers of visual acuity gains in neovascular age-related macular degeneration in real life: findings from the AURA study. Br J Ophthalmol 2016; 100: 1623-1628
    CrossrefPubMedSearch in Google Scholar
  • 39 Eter N, Hasanbasic Z, Keramas G. et al. PERSEUS24-month analysis: a prospective non-interventional study to assess the effectiveness of intravitreal aflibercept in routine clinical practice in Germany in patients with neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2021; 259: 2213-2223
    CrossrefPubMedSearch in Google Scholar
  • 40 Colijn JM, Buitendijk GHS, Prokofyeva E. et al. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology 2017;
    CrossrefPubMedSearch in Google Scholar
  • 41 Delcourt C, Diaz JL, Ponton-Sanchez A. et al. Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à lʼAge. Arch Ophthalmol (Chicago, Ill 1960) 1998; 116: 1031-1035
    CrossrefPubMedSearch in Google Scholar
  • 42 Hogg RE, Wright DM, Quinn NB. et al. Prevalence and risk factors for age-related macular degeneration in a population-based cohort study of older adults in Northern Ireland using multimodal imaging: NICOLA Study. Br J Ophthalmol 2022;
    CrossrefPubMedSearch in Google Scholar
  • 43 Akuffo KO, Nolan J, Stack J. et al. Prevalence of age-related macular degeneration in the Republic of Ireland. Br J Ophthalmol 2015; 99: 1037-1044
    CrossrefPubMedSearch in Google Scholar
  • 44 Yip JLY, Khawaja AP, Chan MPY. et al. Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study. Public Health 2015; 129: 103-109
    CrossrefPubMedSearch in Google Scholar
  • 45 Wilde C, Poostchi A, Mehta RL. et al. Prevalence of age-related macular degeneration in an elderly UK Caucasian population – The Bridlington Eye Assessment Project: a cross-sectional study. Eye 2017;
    CrossrefPubMedSearch in Google Scholar
  • 46 Augood CA, Vingerling JR, de Jong PT. et al. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol 2006; 124: 529-535
    CrossrefPubMedSearch in Google Scholar
  • 47 Klaver CC, Assink JJ, van Leeuwen R. et al. Incidence and progression rates of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci 2001; 42: 2237-2241
    PubMedSearch in Google Scholar
  • 48 Delcourt C, Lacroux A, Carrière I. The three-year incidence of age-related macular degeneration: the “Pathologies Oculaires Liées à lʼAge” (POLA) prospective study. Am J Ophthalmol 2005; 140: 924-926
    CrossrefPubMedSearch in Google Scholar
  • 49 Saunier V, Merle BMJ, Delyfer MN. et al. Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study. JAMA Ophthalmol 2018; 136: 473-481
    CrossrefPubMedSearch in Google Scholar
  • 50 Buch H, Nielsen V N, Vinding T. et al. 14-Year incidence, progression, and visual morbidity of age-related maculopathy: The Copenhagen City Eye Study. Ophthalmology 2005;
    CrossrefPubMedSearch in Google Scholar