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Tierarztl Prax Ausg K Kleintiere Heimtiere 2023; 51(06): 411-421
DOI: 10.1055/a-2191-1723
Übersichtsartikel

Ein Update zur felinen und caninen Giardiose

Feline and canine giardiosis: An Update
Sabrina Kanski
1   Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München
,
Karin Weber
1   Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München
,
Kathrin Busch
1   Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München
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Zusammenfassung

Giardia duodenalis ist ein fakultativ pathogener Darmparasit. Die Giardiose bei Hund und Katze kann symptomatisch oder asymptomatisch verlaufen, wobei typische Symptome Durchfall mit und ohne Erbrechen sind. Die Prävalenz bei Jungtieren ist hoch und kann bis zu 50 % betragen. Es gibt 8 verschiedene Genotypen (A–H), welche als Assemblages bezeichnet werden. Bei Hunden kommen am häufigsten die Assemblages C und D und bei Katzen die Assemblages F und A vor. Tiere können somit auch mit den zoonotischen Assemblages A und B oder auch mit mehreren Genotypen gleichzeitig infiziert sein. Als Diagnostikmethoden werden der Immunfluoreszenztest (IFA), der Enzymimmunoassay (ELISA) und die Fäkalzentrifugation mittels Zinksulfatlösung empfohlen. Mittels Polymerasekettenreation (PCR) kann die entsprechende Assemblage bestimmt werden. Zur Therapie der caninen und felinen Giardiose sind die Wirkstoffe Fenbendazol und Metronidazol zugelassen. Zudem sollten bestimmte Hygienemaßnahmen beachtet werden. Behandelt werden nur symptomatische Tiere oder solche, welche im selben Haushalt mit Risikopatienten (z. B. immunsupprimierten Menschen) leben. Ziel der Behandlung ist die klinische Verbesserung der Symptomatik der erkrankten Hunde und Katzen. Zu einer vollständigen Elimination der Giardien kommt es oftmals nicht.

Abstract

Giardia duodenalis is a facultative pathogenic intestinal parasite. Giardiosis in dogs and cats may appear with or without clinical signs. Typical signs include diarrhea with or without vomiting. The prevalence in young animals is high and may amount to up to 50%. There are 8 different genotypes (A – H), which are called assemblages. Assemblages C and D are most common in dogs and assemblage F most frequent in cats. However, animals may also be infected with the zoonotically effective assemblages A and B or exhibit mixed infections. The immunofluorescence test (IFA), the enzyme-linked immunosorbent assay (ELISA) and fecal centrifugation using zinc sulphate solution are currently recommended as diagnostic methods. Polymerase chain reaction (PCR) may be used to determine the corresponding assemblage. Approved treatments for giardiosis include fenbendazole and metronidazole. In addition, undertaking specific hygiene measures is warranted. Only animals showing clinical signs or those living in the same household with high-risk patients (e. g. immunosuppressed humans) are recommended to receive medication. The aim of treatment is clinical improvement of the diseased dogs and cats. Frequently, complete elimination of Giardia is not attained.

Schlüsselwörter

Giardia duodenalis - Parasiten - Kotuntersuchung - Durchfall - Hund - Katze

Key words

Giardia duodenalis - parasite - fecal examination - diarrhea - dog - cat


Publication History

Received: 02 May 2023

Accepted: 22 June 2023

Article published online:
06 December 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Thompson RC, Palmer CS, O'Handley R. The public health and clinical significance of Giardia and Cryptosporidium in domestic animals. Vet J 2008; 177: 18-25
    CrossrefPubMedSearch in Google Scholar
  • 2 Pallant L, Barutzki D, Schaper R. et al. The epidemiology of infections with Giardia species and genotypes in well cared for dogs and cats in Germany. Parasit Vectors 2015; 8: 2
    CrossrefPubMedSearch in Google Scholar
  • 3 Ballweber LR, Xiao L, Bowman DD. et al. Giardiasis in dogs and cats: update on epidemiology and public health significance. Trends Parasitol 2010; 26: 180-189
    CrossrefPubMedSearch in Google Scholar
  • 4 Barutzki D, Schaper R. Results of parasitological examinations of faecal samples from cats and dogs in Germany between 2003 and 2010. Parasitol Res 2011; 109: S45-S60
    CrossrefPubMedSearch in Google Scholar
  • 5 Little SE, Johnson EM, Lewis D. et al. Prevalence of intestinal parasites in pet dogs in the United States. Vet Parasitol 2009; 166: 144-152
    CrossrefPubMedSearch in Google Scholar
  • 6 Sobotyk C, Upton KE, Lejeune M. et al. Retrospective study of canine endoparasites diagnosed by fecal flotation methods analyzed across veterinary parasitology diagnostic laboratories, United States, 2018. Parasit Vectors 2021; 14: 439
    CrossrefPubMedSearch in Google Scholar
  • 7 Beck W. Giardien – Nr. 1 der Parasiten bei Hund und Katze. teamkonkret. 2020
    PubMed
  • 8 Alves J, Santos A. Prevalence of Giardia spp. in young dogs using a combination of two diagnostic methods. Acta Parasitol 2016; 61: 261-266
    CrossrefPubMedSearch in Google Scholar
  • 9 Salant H, Kuzi S, Navarro D. et al. Prevalence and molecular characterization of Giardia duodenalis in dogs in Israel. Comp Immunol Microbiol Infect Dis 2020; 73: 101548
    CrossrefPubMedSearch in Google Scholar
  • 10 Uiterwijk M, Nijsse R, Kooyman FNJ. et al. Host factors associated with Giardia duodenalis infection in dogs across multiple diagnostic tests. Parasit Vectors 2019; 12: 556
    CrossrefPubMedSearch in Google Scholar
  • 11 Nguyen ST, Fukuda Y, Nguyen DT. et al. Prevalence, genotyping and risk factors of Giardia duodenalis from dogs in Vietnam. J Vet Med Sci 2018; 80: 92-97
    CrossrefPubMedSearch in Google Scholar
  • 12 Barutzki D, Schaper R. Age-dependant prevalence of endoparasites in young dogs and cats up to one year of age. Parasitol Res 2013; 112: 119-131
    CrossrefPubMedSearch in Google Scholar
  • 13 Murnik LC, Daugschies A, Delling C. Gastrointestinal parasites in young dogs and risk factors associated with infection. Parasitol Res 2022; 10.1007/s00436-022-07760-9
    CrossrefPubMedSearch in Google Scholar
  • 14 Ryan UM, Feng Y, Fayer R. et al. Taxonomy and molecular epidemiology of Cryptosporidium and Giardia – a 50 year perspective (1971-2021). Int J Parasitol 2021; 51: 1099-1119
    CrossrefPubMedSearch in Google Scholar
  • 15 Thompson RC, Monis PT. Variation in Giardia: implications for taxonomy and epidemiology. Adv Parasitol 2004; 58: 69-137
    CrossrefPubMedSearch in Google Scholar
  • 16 Leonhard S, Pfister K, Beelitz P. et al. The molecular characterisation of Giardia from dogs in southern Germany. Vet Parasitol 2007; 150: 33-38
    CrossrefPubMedSearch in Google Scholar
  • 17 Feng Y, Xiao L. Zoonotic potential and molecular epidemiology of Giardia species and giardiasis. Clin Microbiol Rev 2011; 24: 110-140
    CrossrefPubMedSearch in Google Scholar
  • 18 Harvey TV, Carvalho J, Aquino MCC. et al. Giardiasis in children and dogs, and the first report of assemblage E in dogs from northeastern Brazil. Rev Bras Parasitol Vet 2023; 32: e012222
    CrossrefPubMedSearch in Google Scholar
  • 19 Adam RD. Giardia duodenalis: Biology and Pathogenesis. Clin Microbiol Rev 2021; 34: e0002419
    CrossrefPubMedSearch in Google Scholar
  • 20 Sprong H, Cacció SM, van der Giessen JW. et al. Identification of zoonotic genotypes of Giardia duodenalis . PLoS Negl Trop Dis 2009; 3: e558
    CrossrefPubMedSearch in Google Scholar
  • 21 Cacció SM, Beck R, Lalle M. et al. Multilocus genotyping of Giardia duodenalis reveals striking differences between assemblages A and B. Int J Parasitol 2008; 38: 1523-1531
    CrossrefPubMedSearch in Google Scholar
  • 22 Pipikova J, Papajova I, Majlathova V. et al. First report on Giardia duodenalis assemblage F in Slovakian children living in poor environmental conditions. J Microbiol Immunol Infect 2020; 53: 148-156
    CrossrefPubMedSearch in Google Scholar
  • 23 Scorza AV, Buch J, Franco P. et al. Evaluation for associations amongst Giardia duodenalis assemblages and diarrhea in dogs. Vet Parasitol 2021; 300: 109581
    CrossrefPubMedSearch in Google Scholar
  • 24 Sui Y, Zhang X, Wang H. et al. Prevalence and genetic diversity of Giardia duodenalis in pet dogs from Zhengzhou, central China and the association between gut microbiota and fecal characteristics during infection. One Health 2022; 14: 100401
    CrossrefPubMedSearch in Google Scholar
  • 25 Guadano Procesi I, Carnio A, Berrilli F. et al. Giardia duodenalis in colony stray cats from Italy. Zoonoses Public Health 2022; 69: 46-54
    CrossrefPubMedSearch in Google Scholar
  • 26 Monis PT, Cacció SM, Thompson RC. Variation in Giardia: towards a taxonomic revision of the genus. Trends Parasitol 2009; 25: 93-100
    CrossrefPubMedSearch in Google Scholar
  • 27 Lasek-Nesselquist E, Welch DM, Sogin ML. The identification of a new Giardia duodenalis assemblage in marine vertebrates and a preliminary analysis of G. duodenalis population biology in marine systems. Int J Parasitol 2010; 40: 1063-1074
    CrossrefPubMedSearch in Google Scholar
  • 28 Asghari A, Ebrahimi M, Shamsi L. et al. Global molecular prevalence of Giardia duodenalis in pigs (Sus domesticus): A systematic review and meta-analysis. Heliyon 2023; 9: e13243
    CrossrefPubMedSearch in Google Scholar
  • 29 Duplessis CA, Gutierrez RL, Porter CK. Review: chronic and persistent diarrhea with a focus in the returning traveler. Trop Dis Travel Med Vaccines 2017; 3: 9
    CrossrefPubMedSearch in Google Scholar
  • 30 Control ECfDPa. Giardiasis (lambliasis) – Annual Epidemiological Report for 2019 https://wwwecdceuropaeu/sites/default/files/documents/giardiasis-%20annual-epidemiological-report-2019_0pdf 2022
    PubMed
  • 31 Espelage W. an der Heiden M, Stark K et al. Characteristics and risk factors for symptomatic Giardia lamblia infections in Germany. BMC Public Health 2010; 10: 41
    CrossrefPubMedSearch in Google Scholar
  • 32 Wittler RR. Foodborne and Waterborne Illness. Pediatr Rev 2023; 44: 81-91
    CrossrefPubMedSearch in Google Scholar
  • 33 Krumrie S, Capewell P, Smith-Palmer A. et al. A scoping review of risk factors and transmission routes associated with human giardiasis outbreaks in high-income settings. Curr Res Parasitol Vector Borne Dis 2022; 2: 100084
    CrossrefPubMedSearch in Google Scholar
  • 34 Laishram S, Kang G, Ajjampur SS. Giardiasis: a review on assemblage distribution and epidemiology in India. Indian J Gastroenterol 2012; 31: 3-12
    CrossrefPubMedSearch in Google Scholar
  • 35 Institut R-K. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten für . 2020 In; 2020
    PubMed
  • 36 Sommer MF, Rupp P, Pietsch M. et al. Giardia in a selected population of dogs and cats in Germany – diagnostics, coinfections and assemblages. Vet Parasitol 2018; 249: 49-56
    CrossrefPubMedSearch in Google Scholar
  • 37 M.E. H. Children at risk of giardiasis in Auckland: a case–control analysis. 2003.
    PubMed
  • 38 Hoque ME, Hope VT, Kjellstrom T. et al. Risk of giardiasis in Aucklanders: a case-control study. Int J Infect Dis 2002; 6: 191-197
    CrossrefPubMedSearch in Google Scholar
  • 39 Stuart JM, Orr HJ, Warburton FG. et al. Risk factors for sporadic giardiasis: a case-control study in southwestern England. Emerg Infect Dis 2003; 9: 229-233
    CrossrefPubMedSearch in Google Scholar
  • 40 Inpankaew T, Traub R, Thompson RC. et al. Canine parasitic zoonoses in Bangkok temples. Southeast Asian J Trop Med Public Health 2007; 38: 247-255
    PubMedSearch in Google Scholar
  • 41 Traub RJ, Robertson ID, Irwin P. et al. Humans, dogs and parasitic zoonoses--unravelling the relationships in a remote endemic community in northeast India using molecular tools. Parasitol Res 2003; 90: S156-S157
    CrossrefPubMedSearch in Google Scholar
  • 42 Traub RJ, Monis PT, Robertson I. et al. Epidemiological and molecular evidence supports the zoonotic transmission of Giardia among humans and dogs living in the same community. Parasitology 2004; 128: 253-262
    CrossrefPubMedSearch in Google Scholar
  • 43 Volotao AC, Costa-Macedo LM, Haddad FS. et al. Genotyping of Giardia duodenalis from human and animal samples from Brazil using beta-giardin gene: a phylogenetic analysis. Acta Trop 2007; 102: 10-19
    CrossrefPubMedSearch in Google Scholar
  • 44 Xiao L, Fayer R. Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission. Int J Parasitol 2008; 38: 1239-1255
    CrossrefPubMedSearch in Google Scholar
  • 45 Marangi M, Berrilli F, Otranto D. et al. Genotyping of Giardia duodenalis among children and dogs in a closed socially deprived community from Italy. Zoonoses Public Health 2010; 57: e54-e58
    CrossrefPubMedSearch in Google Scholar
  • 46 Stark D, Barratt JL, van Hal S. et al. Clinical significance of enteric protozoa in the immunosuppressed human population. Clin Microbiol Rev 2009; 22: 634-650
    CrossrefPubMedSearch in Google Scholar
  • 47 Boyd WP, Bachman BA. Gastrointestinal infections in the compromised host. Med Clin North Am 1982; 66: 743-753
    CrossrefPubMedSearch in Google Scholar
  • 48 Faubert G. Immune response to Giardia duodenalis . Clin Microbiol Rev 2000; 13: 35-54 table of contents
    CrossrefPubMedSearch in Google Scholar
  • 49 Malamut G, Verkarre V, Suarez F. et al. The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease. Am J Gastroenterol 2010; 105: 2262-2275
    CrossrefPubMedSearch in Google Scholar
  • 50 Yazdani R, Habibi S, Sharifi L. et al. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management. J Investig Allergol Clin Immunol 2020; 30: 14-34
    CrossrefPubMedSearch in Google Scholar
  • 51 Swain S, Selmi C, Gershwin ME. et al. The clinical implications of selective IgA deficiency. J Transl Autoimmun 2019; 2: 100025
    CrossrefPubMedSearch in Google Scholar
  • 52 Diaz-Alberola I, Gutierrez-Bautista JF, Espuch-Oliver A. et al. Incidence, Management Experience and Characteristics of Patients with Giardiasis and Common Variable Immunodeficiency. J Clin Med 2022; 11
    CrossrefPubMedSearch in Google Scholar
  • 53 Bouzid M, Halai K, Jeffreys D. et al. The prevalence of Giardia infection in dogs and cats, a systematic review and meta-analysis of prevalence studies from stool samples. Vet Parasitol 2015; 207: 181-202
    CrossrefPubMedSearch in Google Scholar
  • 54 Deutsche Adaption der ESCCAP-Empfehlung Nr. 6 J. Bekämpfung von intestinalen Protozoen bei Hunden und Katzen. 2017.
    PubMed
  • 55 Jacobs SR, Forrester CP, Yang J. A survey of the prevalence of Giardia in dogs presented to Canadian veterinary practices. Can Vet J 2001; 42: 45-46
    PubMedSearch in Google Scholar
  • 56 Itoh N, Muraoka N, Kawamata J. et al. Prevalence of Giardia intestinalis infection in household cats of Tohoku district in Japan. J Vet Med Sci 2006; 68: 161-163
    CrossrefPubMedSearch in Google Scholar
  • 57 Thompson RC, Reynoldson JA, Mendis AH. Giardia and giardiasis. Adv Parasitol 1993; 32: 71-160
    CrossrefPubMedSearch in Google Scholar
  • 58 Allain T, Buret AG. Pathogenesis and post-infectious complications in giardiasis. Adv Parasitol 2020; 107: 173-199
    CrossrefPubMedSearch in Google Scholar
  • 59 Einarsson E, Ma'ayeh S, Svard SG. An up-date on Giardia and giardiasis. Curr Opin Microbiol 2016; 34: 47-52
    CrossrefPubMedSearch in Google Scholar
  • 60 Katelaris PH, Farthing MJ. Diarrhoea and malabsorption in giardiasis: a multifactorial process. Gut 1992; 33: 295-297
    CrossrefPubMedSearch in Google Scholar
  • 61 Ankarklev J, Jerlstrom-Hultqvist J, Ringqvist E. et al. Behind the smile: cell biology and disease mechanisms of Giardia species. Nat Rev Microbiol 2010; 8: 413-422
    CrossrefPubMedSearch in Google Scholar
  • 62 Roxstrom-Lindquist K, Palm D, Reiner D. et al. Giardia immunity--an update. Trends Parasitol 2006; 22: 26-31
    CrossrefPubMedSearch in Google Scholar
  • 63 Dixon BR. Giardia duodenalis in humans and animals – Transmission and disease. Res Vet Sci 2021; 135: 283-289
    CrossrefPubMedSearch in Google Scholar
  • 64 Erickson MC, Ortega YR. Inactivation of protozoan parasites in food, water, and environmental systems. J Food Prot 2006; 69: 2786-2808
    CrossrefPubMedSearch in Google Scholar
  • 65 Adam RD. Biology of Giardia lamblia . Clin Microbiol Rev 2001; 14: 447-475
    CrossrefPubMedSearch in Google Scholar
  • 66 Lauwaet T, Davids BJ, Reiner DS. et al. Encystation of Giardia lamblia: a model for other parasites. Curr Opin Microbiol 2007; 10: 554-559
    CrossrefPubMedSearch in Google Scholar
  • 67 Hagen KD, Hirakawa MP, House SA. et al. Novel structural components of the ventral disc and lateral crest in Giardia intestinalis . PLoS Negl Trop Dis 2011; 5: e1442
    CrossrefPubMedSearch in Google Scholar
  • 68 Friend DS. The fine structure of Giardia muris . J Cell Biol 1966; 29: 317-332
    CrossrefPubMedSearch in Google Scholar
  • 69 Gillin FD, Reiner DS, McCaffery JM. Cell biology of the primitive eukaryote Giardia lamblia . Annu Rev Microbiol 1996; 50: 679-705
    CrossrefPubMedSearch in Google Scholar
  • 70 Palm D, Weiland M, McArthur AG. et al. Developmental changes in the adhesive disk during Giardia differentiation. Mol Biochem Parasitol 2005; 141: 199-207
    CrossrefPubMedSearch in Google Scholar
  • 71 Paget TA, Macechko PT, Jarroll EL. Metabolic changes in Giardia intestinalis during differentiation. J Parasitol 1998; 84: 222-226
    CrossrefPubMedSearch in Google Scholar
  • 72 Halliez MC, Buret AG. Extra-intestinal and long term consequences of Giardia duodenalis infections. World J Gastroenterol 2013; 19: 8974-8985
    CrossrefPubMedSearch in Google Scholar
  • 73 Cotton JA, Beatty JK, Buret AG. Host parasite interactions and pathophysiology in Giardia infections. Int J Parasitol 2011; 41: 925-933
    CrossrefPubMedSearch in Google Scholar
  • 74 Scott KG, Yu LC, Buret AG. Role of CD8+and CD4+T lymphocytes in jejunal mucosal injury during murine giardiasis. Infect Immun 2004; 72: 3536-3542
    CrossrefPubMedSearch in Google Scholar
  • 75 Buret AG. Pathophysiology of enteric infections with Giardia duodenalius . Parasite 2008; 15: 261-265
    CrossrefPubMedSearch in Google Scholar
  • 76 Chin AC, Teoh DA, Scott KG. et al. Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner. Infect Immun 2002; 70: 3673-3680
    CrossrefPubMedSearch in Google Scholar
  • 77 Troeger H, Epple HJ, Schneider T. et al. Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut 2007; 56: 328-335
    CrossrefPubMedSearch in Google Scholar
  • 78 Panaro MA, Cianciulli A, Mitolo V. et al. Caspase-dependent apoptosis of the HCT-8 epithelial cell line induced by the parasite Giardia intestinalis . FEMS Immunol Med Microbiol 2007; 51: 302-309
    CrossrefPubMedSearch in Google Scholar
  • 79 Oberhuber G, Kastner N, Stolte M. Giardiasis: a histologic analysis of 567 cases. Scand J Gastroenterol 1997; 32: 48-51
    CrossrefPubMedSearch in Google Scholar
  • 80 Scott KG, Logan MR, Klammer GM. et al. Jejunal brush border microvillous alterations in Giardia muris-infected mice: role of T lymphocytes and interleukin-6. Infect Immun 2000; 68: 3412-3418
    CrossrefPubMedSearch in Google Scholar
  • 81 Buret AG. Mechanisms of epithelial dysfunction in giardiasis. Gut 2007; 56: 316-317
    CrossrefPubMedSearch in Google Scholar
  • 82 Gorowara S, Ganguly NK, Mahajan RC. et al. Study on the mechanism of Giardia lamblia induced diarrhoea in mice. Biochim Biophys Acta 1992; 1138: 122-126
    CrossrefPubMedSearch in Google Scholar
  • 83 Scott KG, Meddings JB, Kirk DR. et al. Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology 2002; 123: 1179-1190
    CrossrefPubMedSearch in Google Scholar
  • 84 Fink MY, Singer SM. The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis. Trends Parasitol 2017; 33: 901-913
    CrossrefPubMedSearch in Google Scholar
  • 85 Buret AG, Mitchell K, Muench DG. et al. Giardia lamblia disrupts tight junctional ZO-1 and increases permeability in non-transformed human small intestinal epithelial monolayers: effects of epidermal growth factor. Parasitology 2002; 125: 11-19
    CrossrefPubMedSearch in Google Scholar
  • 86 Gates MC, Nolan TJ. Endoparasite prevalence and recurrence across different age groups of dogs and cats. Vet Parasitol 2009; 166: 153-158
    CrossrefPubMedSearch in Google Scholar
  • 87 Gultekin M, Ural K, Aysul N. et al. Prevalence and molecular characterization of Giardia duodenalis in dogs in Aydin, Turkey. Int J Environ Health Res 2017; 27: 161-168
    CrossrefPubMedSearch in Google Scholar
  • 88 Tzannes S, Batchelor DJ, Graham PA. et al. Prevalence of Cryptosporidium, Giardia and Isospora species infections in pet cats with clinical signs of gastrointestinal disease. J Feline Med Surg 2008; 10: 1-8
    CrossrefPubMedSearch in Google Scholar
  • 89 Batchelor DJ, Tzannes S, Graham PA. et al. Detection of endoparasites with zoonotic potential in dogs with gastrointestinal disease in the UK. Transbound Emerg Dis 2008; 55: 99-104
    CrossrefPubMedSearch in Google Scholar
  • 90 Mundim MJ, Rosa LA, Hortencio SM. et al. Prevalence of Giardia duodenalis and Cryptosporidium spp. in dogs from different living conditions in Uberlandia, Brazil. Vet Parasitol 2007; 144: 356-359
    CrossrefPubMedSearch in Google Scholar
  • 91 Fontanarrosa MF, Vezzani D, Basabe J. et al. An epidemiological study of gastrointestinal parasites of dogs from Southern Greater Buenos Aires (Argentina): age, gender, breed, mixed infections, and seasonal and spatial patterns. Vet Parasitol 2006; 136: 283-295
    CrossrefPubMedSearch in Google Scholar
  • 92 Agresti A, Berrilli F, Maestrini M. et al. Prevalence, Risk Factors and Genotypes of Giardia duodenalis in Sheltered Dogs in Tuscany (Central Italy. Pathogens 2021; 11
    CrossrefPubMedSearch in Google Scholar
  • 93 Capelli G, Frangipane di Regalbono A, Iorio R. et al. Giardia species and other intestinal parasites in dogs in north-east and central Italy. Vet Rec 2006; 159: 422-424
    CrossrefPubMedSearch in Google Scholar
  • 94 Tangtrongsup S, Scorza V. Update on the diagnosis and management of Giardia spp infections in dogs and cats. Top Companion Anim Med 2010; 25: 155-162
    CrossrefPubMedSearch in Google Scholar
  • 95 Decock C, Cadiergues MC, Larcher M. et al. Comparison of two techniques for diagnosis of giardiasis in dogs. Parasite 2003; 10: 69-72
    CrossrefPubMedSearch in Google Scholar
  • 96 Saleh MN, Heptinstall JR, Johnson EM. et al. Comparison of diagnostic techniques for detection of Giardia duodenalis in dogs and cats. J Vet Intern Med 2019; 33: 1272-1277
    CrossrefPubMedSearch in Google Scholar
  • 97 Soares R, Tasca T. Giardiasis: an update review on sensitivity and specificity of methods for laboratorial diagnosis. J Microbiol Methods 2016; 129: 98-102
    CrossrefPubMedSearch in Google Scholar
  • 98 Institut R-K https://www.rki.de/DE/Content/Infekt/IfSG/Falldefinition/Downloads/Falldefinitionen_des_RKI_2019.pdf?__blob=publicationFile Abruf zuletzt am 19.01.2023
    PubMed
  • 99 Tysnes KR, Skancke E, Robertson LJ. Subclinical Giardia in dogs: a veterinary conundrum relevant to human infection. Trends Parasitol 2014; 30: 520-527
    CrossrefPubMedSearch in Google Scholar
  • 100 Geurden T, Berkvens D, Casaert S. et al. A Bayesian evaluation of three diagnostic assays for the detection of Giardia duodenalis in symptomatic and asymptomatic dogs. Vet Parasitol 2008; 157: 14-20
    CrossrefPubMedSearch in Google Scholar
  • 101 Moritz A. Klinische Labordiagnostik in der Tiermedizin. 2017 Hrsg. 7., vollständig überarbeitete und erweiterte Auflage
    PubMed
  • 102 Barutzki DS R, Thompson A. Die Giardiose des Hundes – eine weit verbreitete Erkrankung in Deutschland. kleintier konkret. 2008
    PubMedSearch in Google Scholar
  • 103 GESTIS-Stoffdatenbank https://gestis.dguv.de/data?name=010520 Abruf zuletzt 19.01.2023.
    PubMed
  • 104 GESTIS-Stoffdatenbank https://gestis.dguv.de/data?name=013600 Abruf zuletzt am 19.01.2023.
    PubMed
  • 105 Berg JM, Tymoczko JL, Gatto GJ, Stryer L. Stryer – Biochemie. 2017
    PubMed
  • 106 Papini R, Carreras G, Marangi M. et al. Use of a commercial enzyme-linked immunosorbent assay for rapid detection of Giardia duodenalis in dog stools in the environment: a Bayesian evaluation. J Vet Diagn Invest 2013; 25: 418-422
    CrossrefPubMedSearch in Google Scholar
  • 107 Barbecho JM, Bowman DD, Liotta JL. Comparative performance of reference laboratory tests and in-clinic tests for Giardia in canine feces. Parasit Vectors 2018; 11: 444
    CrossrefPubMedSearch in Google Scholar
  • 108 Uehlinger FD, Naqvi SA, Greenwood SJ. et al. Comparison of five diagnostic tests for Giardia duodenalis in fecal samples from young dogs. Vet Parasitol 2017; 244: 91-96
    CrossrefPubMedSearch in Google Scholar
  • 109 Adeyemo FE, Singh G, Reddy P. et al. Methods for the detection of Cryptosporidium and Giardia: From microscopy to nucleic acid based tools in clinical and environmental regimes. Acta Trop 2018; 184: 15-28
    CrossrefPubMedSearch in Google Scholar
  • 110 Kim RH, Brinster NK. Practical Direct Immunofluorescence. Am J Dermatopathol 2020; 42: 75-85
    CrossrefPubMedSearch in Google Scholar
  • 111 Alles AJ, Waldron MA, Sierra LS. et al. Prospective comparison of direct immunofluorescence and conventional staining methods for detection of Giardia and Cryptosporidium spp. in human fecal specimens. J Clin Microbiol 1995; 33: 1632-1634
    CrossrefPubMedSearch in Google Scholar
  • 112 Rishniw M, Liotta J, Bellosa M. et al. Comparison of 4 Giardia diagnostic tests in diagnosis of naturally acquired canine chronic subclinical giardiasis. J Vet Intern Med 2010; 24: 293-297
    CrossrefPubMedSearch in Google Scholar
  • 113 Ballweber LR, Beugnet F, Marchiondo AA. et al. American Association of Veterinary Parasitologists' review of veterinary fecal flotation methods and factors influencing their accuracy and use--is there really one best technique?. Vet Parasitol 2014; 204: 73-80
    CrossrefPubMedSearch in Google Scholar
  • 114 Zajac AM. Evaluation of the importance of centrifugation as a component of zinc sulfate fecal flotation examinations. 2002
    PubMed
  • 115 Uchoa FFM, Sudre AP, Campos SDE. et al. Assessment of the diagnostic performance of four methods for the detection of Giardia duodenalis in fecal samples from human, canine and feline carriers. J Microbiol Methods 2018; 145: 73-78
    CrossrefPubMedSearch in Google Scholar
  • 116 Ryan U, Zahedi A. Molecular epidemiology of giardiasis from a veterinary perspective. Adv Parasitol 2019; 106: 209-254
    CrossrefPubMedSearch in Google Scholar
  • 117 Traub RJ, Inpankaew T, Reid SA. et al. Transmission cycles of Giardia duodenalis in dogs and humans in Temple communities in Bangkok--a critical evaluation of its prevalence using three diagnostic tests in the field in the absence of a gold standard. Acta Trop 2009; 111: 125-132
    CrossrefPubMedSearch in Google Scholar
  • 118 Ciuca L, Pepe P, Bosco A. et al. Effectiveness of Fenbendazole and Metronidazole Against Giardia Infection in Dogs Monitored for 50-Days in Home-Conditions. Front Vet Sci 2021; 8: 626424
    CrossrefPubMedSearch in Google Scholar
  • 119 Morgan UM. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. 1993
    PubMedSearch in Google Scholar
  • 120 Tiergesundheit M. https://www.msd-tiergesundheit.de/produkte/panacur-tabletten-500-mg/ Abruf zuletzt am 18.12.2022
    PubMed
  • 121 MacDonald LM, Armson A, Thompson AR. et al. Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum . Mol Biochem Parasitol 2004; 138: 89-96
    CrossrefPubMedSearch in Google Scholar
  • 122 Barr SC, Bowman DD, Heller RL. Efficacy of fenbendazole against giardiasis in dogs. Am J Vet Res 1994; 55: 988-990
    CrossrefPubMedSearch in Google Scholar
  • 123 Kaufmann H, Zenner L, Benabed S. et al. Lack of efficacy of fenbendazole against Giardia duodenalis in a naturally infected population of dogs in France. Parasite 2022; 29: 49
    CrossrefPubMedSearch in Google Scholar
  • 124 Barko PC, McMichael MA, Swanson KS. et al. The Gastrointestinal Microbiome: A Review. J Vet Intern Med 2018; 32: 9-25
    CrossrefPubMedSearch in Google Scholar
  • 125 Faure L. A Field Clinical Study to Confirm the Efficacy & Safety of a Metronidazole- based Oral Suspension in Dogs Naturally Infested by Giardiasis: Comparison to Fenbendazole. 2018
    PubMed
  • 126 Lee NN, Bidot WA, Ericsson AC. et al Effects of Giardia lamblia Colonization and Fenbendazole Treatment on Canine Fecal Microbiota. J Am Assoc Lab Anim Sci 2020; 10.30802/AALAS-JAALAS-19-000113
    CrossrefPubMedSearch in Google Scholar
  • 127 Schwartz RD, Donoghue AR, Baggs RB. et al. Evaluation of the safety of fenbendazole in cats. Am J Vet Res 2000; 61: 330-332
    CrossrefPubMedSearch in Google Scholar
  • 128 Fujishiro M, Lidbury JA, Pilla R, Steiner JM, Lappin MR, Suchodolski JS. Evaluation of the effects of anthelmintic administration on the fecal microbiome of healthy dogs with and without subclinical Giardia spp. and Cryptosporidium canis infections. PLoS One. 2020
    PubMedSearch in Google Scholar
  • 129 Dingsdag SA, Hunter N. Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms. J Antimicrob Chemother 2018; 73: 265-279
    CrossrefPubMedSearch in Google Scholar
  • 130 Ordonez-Quiroz A, Ortega-Pierres MG, Bazan-Tejeda ML. et al. DNA damage induced by metronidazole in Giardia duodenalis triggers a DNA homologous recombination response. Exp Parasitol 2018; 194: 24-31
    CrossrefPubMedSearch in Google Scholar
  • 131 Leitsch D. A review on metronidazole: an old warhorse in antimicrobial chemotherapy. Parasitology 2019; 146: 1167-1178
    CrossrefPubMedSearch in Google Scholar
  • 132 Riches A, Hart CJS, Trenholme KR. et al. Anti-Giardia Drug Discovery: Current Status and Gut Feelings. J Med Chem 2020; 63: 13330-13354
    CrossrefPubMedSearch in Google Scholar
  • 133 Pilla R, Gaschen FP, Barr JW. et al. Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. J Vet Intern Med 2020; 34: 1853-1866
    CrossrefPubMedSearch in Google Scholar
  • 134 Chaitman J, Ziese AL, Pilla R. et al. Fecal Microbial and Metabolic Profiles in Dogs With Acute Diarrhea Receiving Either Fecal Microbiota Transplantation or Oral Metronidazole. Front Vet Sci 2020; 7: 192
    CrossrefPubMedSearch in Google Scholar
  • 135 Caylor KB, Cassimatis MK. Metronidazole neurotoxicosis in two cats. J Am Anim Hosp Assoc 2001; 37: 258-262
    CrossrefPubMedSearch in Google Scholar
  • 136 Olson EJ, Morales SC, McVey AS. et al. Putative metronidazole neurotoxicosis in a cat. Vet Pathol 2005; 42: 665-669
    CrossrefPubMedSearch in Google Scholar
  • 137 Tauro A, Beltran E, Cherubini GB. et al. Metronidazole-induced neurotoxicity in 26 dogs. Aust Vet J 2018; 96: 495-501
    CrossrefPubMedSearch in Google Scholar
  • 138 Dow SW, LeCouteur RA, Poss ML. et al. Central nervous system toxicosis associated with metronidazole treatment of dogs: five cases (1984-1987). J Am Vet Med Assoc 1989; 195: 365-368
    PubMedSearch in Google Scholar
  • 139 Payne PA, Ridley RK, Dryden MW. et al. Efficacy of a combination febantel-praziquantel-pyrantel product, with or without vaccination with a commercial Giardia vaccine, for treatment of dogs with naturally occurring giardiasis. J Am Vet Med Assoc 2002; 220: 330-333
    CrossrefPubMedSearch in Google Scholar
  • 140 Giangaspero A, Traldi G, Paoletti B. et al. Efficacy of pyrantel embonate, febantel and praziquantel against Giardia species in naturally infected adult dogs. Vet Rec 2002; 150: 184-186
    CrossrefPubMedSearch in Google Scholar
  • 141 Montoya A, Dado D, Mateo M. et al. Efficacy of Drontal Flavour Plus (50 mg praziquantel, 144 mg pyrantel embonate, 150 mg febantel per tablet) against Giardia sp in naturally infected dogs. Parasitol Res 2008; 103: 1141-1144
    CrossrefPubMedSearch in Google Scholar
  • 142 Olson ME, Heine J. Synergistic effect of febantel and pyrantel embonate in elimination of Giardia in a gerbil model. Parasitol Res 2009; 105: S135-S140
    CrossrefPubMedSearch in Google Scholar
  • 143 Bowman DD, Liotta JL, Ulrich M. et al. Treatment of naturally occurring, asymptomatic Giardia sp. in dogs with Drontal Plus flavour tablets. Parasitol Res 2009; 105: S125-S134
    CrossrefPubMedSearch in Google Scholar
  • 144 Fiechter R, Deplazes P, Schnyder M. Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel. Vet Parasitol 2012; 187: 93-98
    CrossrefPubMedSearch in Google Scholar
  • 145 Zanzani SA, Gazzonis AL, Scarpa P. et al. Coinfection with Tritrichomonas foetus and Giardia duodenalis in Two Cats with Chronic Diarrhea. Case Rep. Vet Med 2016; 2016: 5705168
    CrossrefPubMedSearch in Google Scholar
  • 146 (BTK) B. Leitlinien für den sorgfältigen Umgang mit antibakteriell wirksamen Tierarzneimitteln. 2015
    PubMed
  • 147 Zajac AM, LaBranche TP, Donoghue AR. et al. Efficacy of fenbendazole in the treatment of experimental Giardia infection in dogs. Am J Vet Res 1998; 59: 61-63
    CrossrefPubMedSearch in Google Scholar
  • 148 Barr SC, Bowman DD, Frongillo MF. et al. Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs. Am J Vet Res 1998; 59: 1134-1136
    CrossrefPubMedSearch in Google Scholar
  • 149 Council CAP https://capcvet.org/guidelines/giardia/ Abruf zuletzt am 18.12.2022
    PubMed