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Int J Sports Med 2024; 45(13): 994-1004
DOI: 10.1055/a-2348-2684
Clinical Sciences

Exercise Improves Respiratory Function, Body Fluid and Nitric Oxide in Hemodialysis Patients

Rodrigo Vanerson Passos Neves
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Hugo Luca Corrêa
2   Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Andrea Lucena Reis
2   Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Rosangela Vieira Andrade
3   Graduate Program in Biotechnology, Catholic University of Brasilia, Taguatinga, Brazil
,
Thais Branquinho Araújo
2   Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Rafael Lavarini Santos
4   Graduate Program in Genomic Science and Biotechnology, Catholic University of Brasilia, Taguatinga, Brazil
,
Fernanda Félix Santos Oliveira
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Guilherme Eduardo Barbosa Moraes Araújo
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
André Victor Gulyas Marra
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Thaís Amaral Baracho
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Taynah Oliveira Martins
5   Graduate Program in Physical Education, Catholic University of Brasilia, Riacho Fundo I, Brazil
,
Jessica Mycaelle da Silva Barbosa
6   Nutrition, Catholic University of Brasilia, Taguatinga, Brazil
,
Mariana Neiva Garcia
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Nicole Messenberg Guimarães Miller
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Lysleine Alves Deus 
1   Graduate Programm in Physical Education, Catholic University of Brasilia, Taguatinga, Brazil
,
Thiago dos Santos Rosa
7   Graduate Program in Physical Education and Graduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasilia, Taguatinga, Brazil
› Institutsangaben Funding Information This study was financed in part by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) with grants from:– CNPq/MESP nº 19/2023 - Estudos e pesquisas voltados para a pesquisa, desenvolvimento, inovação e extensão em esporte e atividade física and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance code 001. This work was funded by the Fundação de Apoio à Pesquisa do Distrito Federal (FAP/DF) with grants from: demanda espontânea –Edital 09/2022.
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Abstract

Emerging evidence suggests that resistance training (RT) can mitigate respiratory muscle weakness in hemodialysis (HD) patients. However, the underlying mechanisms responsible for these beneficial effects remain unclear. The purpose of this study was to assess the impact of periodized RT on respiratory muscle strength and its relationship with handgrip strength (HGS), fat-free mass (FFM), nitric oxide (NO), and interdialytic weight gain (IWG) in HD patients. Thirty-three patients were randomly assigned to two groups: control (CTL; n=18) and RT (n=15). The RT group did not perform any additional exercise training specific to the respiratory tract. Maximal inspiratory (MIP) and expiratory (MEP) pressures, peak expiratory flow (PEF), HGS, FFM, NO, and IWG were measured before and after the intervention period. Participants in the RT group engaged in a 24-week RT program, three times per week. RT resulted in significant improvements in MIP, MEP, PEF, as well as enhancements in HGS, FFM, NO, and IWG (p<0.05). Notably, inverse correlations were observed between MIP (r=−0.37, p=0.03) and PEF (r=−0.4, p=0.02) with IWG. Thus, the amelioration of HGS and FFM coincided with a reduction in respiratory muscle weakness among HD patients. Decreased IWG and increased circulating NO are plausible mechanisms contributing to these improvements.

Keywords

exercise - end-stage renal disease - respiratory performance - lung - endothelial dysfunction - edema


Publikationsverlauf

Eingereicht: 10. Dezember 2023

Angenommen: 18. Juni 2024

Accepted Manuscript online:
19. Juni 2024

Artikel online veröffentlicht:
31. Juli 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

Leserbrief zu diesem Artikel:

Response to the Comments on: “Nutritional status should be considered a crucial issue regarding the effects of exercise”Int J Sports Med 2024; 45(13): 1025-1025
DOI: 10.1055/a-2434-9828

Leserbrief zu diesem Artikel:

Nutritional status should be considered a crucial issue regarding the effects of exerciseInt J Sports Med 2024; 45(13): 1023-1024
DOI: 10.1055/a-2427-6120

 

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