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Thromb Haemost 2025; 125(02): 093-096
DOI: 10.1055/a-2348-5697
Review Article

Monocyte Subsets in Cardiovascular Disease: A Biomarker Perspective

Michael Hristov
1   Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten (IPEK), Ludwig-Maximilians-Universität (LMU), München, Germany
,
Christian Weber
1   Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten (IPEK), Ludwig-Maximilians-Universität (LMU), München, Germany
2   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), München, Germany
3   Munich Cluster for Systems Neurology (SyNergy), München, Germany
4   Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands
› Institutsangaben
Funding The authors are supported by the Deutsche Forschungsgemeinschaft (SFB 1123) and the August-Lenz-Stiftung.
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Abstract

Endothelial dysfunctions together with a dysregulated immune response and lipid accumulation are important confounding factors in the onset and chronic development of atherosclerosis. Recently, a large body of data has emerged on the sequential involvement of different immune cell types, including monocytes, in the pathology of this disease. In this condensed review, we aim to highlight some of the recent basic research and clinical findings on monocyte subsets published since our joint European Society of Cardiology consensus document, and re-evaluate their potential relevance as surrogate biomarkers in coronary artery disease.

Keywords

monocytes - atherosclerosis - leukocytes - activation

The review process for this paper was fully handled by Gregory Y. H. Lip, Editor in Chief.




Publikationsverlauf

Eingereicht: 30. April 2024

Angenommen: 18. Juni 2024

Accepted Manuscript online:
19. Juni 2024

Artikel online veröffentlicht:
06. Juli 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

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