DOI: 10.1055/b-002-91657
Lee, Michael J; Norvell, Daniel C; Dettori, Joseph R; et al.: 2013

SMART Approach to Spine Clinical Research

Print ISBN 9783131750617 · Online ISBN 9783131750716
More Information

Book

Editors: Lee, Michael J; Norvell, Daniel C; Dettori, Joseph R; Skelly, Andrea C; Chapman, Jens R

Authors: Anderson, Paul A; Brodt, Erika D; Cheng, Joseph S; Fehlings, Michael G; Henrickson, Nora B; Hermsmeyer, Jeffrey T

Title: SMART Approach to Spine Clinical Research

Print ISBN: 9783131750617; Online ISBN: 9783131750716; Book DOI: 10.1055/b-002-91657

2013 © 2013 Georg Thieme Verlag KG
Georg Thieme Verlag KG, Stuttgart

Subjects: Orthopaedics and Trauma Surgery;Neurology, Neuropathology, Clinical Neuroscience

Thieme Clinical Collections (English Language)



Front Matter
SMART-B: overview of study conceptualization and planning
Introduction
Study question
Searching the literature
Study design
Measurement
Analysis
Resources and funding
Timing
Bias reduction
Summary
Constructing a SMART study question
Introduction
Initial refinement of your study question
Conceptualizing your study in terms of PICO or PPO
Summary
Constructing a SMART literature search
Introduction
Databases and search engines
A quick search
Structuring a formal search—the basics
The language of searches in PubMed
Combining search terms and wild cards
Filters (Limits)
Putting it all together—an example and considerations for study design
Summary
References
Importance and implications of study design selection
Introduction
Descriptive studies
Analytic studies
Summary
References
Measurements: the backbone of the study
Introduction
Categories of measurement
Selecting outcomes
Minimizing bias in outcomes measurements
Sample size considerations in outcome selection
Why are you collecting the measurements?
Case example
Summary
References
Analysis: basic statistical methods and principles
Introduction
Understanding your measurement variables
Power and sample size calculations
Developing your data collection forms and database
Analysis plan
SMART analysis plan checklist
Summary
References
Resources and Timing
Introduction
Building your team and a network of collaborators
Can you proceed without funding? What funding options do you have?
Possible funding sources
What is the cost of data collection and study operations?
Timing
Summary
Bias reduction: how to avoid spurious conclusions
Introduction
Selection bias
Attrition bias
Performance bias
Measurement or detection bias
Reporting bias
Summary
References
Special topics
Introduction
Manuscript preparation: being SMART about getting published
Heterogeneity of treatment effects
Planning a SMART Registry
Systematic reviews, comparative effectiveness, and health technology assessments
The SMART use of meta-analyses
Healthcare policy: evolution, evidence, and appraisal
Annex