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Planta Med 2008; 74(14): 1720-1729
DOI: 10.1055/s-0028-1088312
Original Paper
Natural Products Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Characterization of Chemical Constituents in Guan Xin II Decoction by Liquid Chromatography Coupled with Electrospray Ionization-Mass Spectrometry

Xue Qiao1 , Jian Han1 , Man Xu1 , Zi-chuan Zhang1 , Shi-feng Sun1 , Hui-feng Li1 , Bao-rong Wang1 , Min Ye1 , De-an Guo1
  • 1The State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P. R. China
Further Information

Publication History

Received: April 2, 2008 Revised: July 7, 2008

Accepted: July 23, 2008

Publication Date:
04 November 2008 (online)

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Abstract

Guan Xin II decoction (GX II) is a widely used traditional Chinese medicine (TCM) formula for the treatment of coronary heart diseases. However, the comprehensive chemical analysis of the formulated GX II is not clarified yet. An HPLC-DAD-ESI-MSn method was established to analyze GX II and its five component herbs, respectively. A total of 57 compounds, including phenolic acids, glycosides, flavonoids, and alkaloids were identified or tentatively characterized on the basis of their mass spectra or by comparison with reference standards. This is the first time that the chemical composition of GX II was elucidated by LC/MS. The established method will be used for quality control and pharmacokinetic studies of GX II.

Abbreviations

GX II:Guan Xin II, Guan Xin Er Hao (in Chinese)

TCM:traditional Chinese medicine

Key words

chemical analysis - Chinese medicine - Guan Xin II decoction - HPLC-DAD-ESI-MSn

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Prof. Dr. De-an Guo

The State Key Laboratory of Natural and Biomimetic Drugs

School of Pharmaceutical Sciences

Peking University

38 Xueyuan Road

Beijing 100083

People’s Republic of China

Phone: +86-10-8280-1516

Fax: +86-10-8280-2700

Email: gda@bjmu.edu.cn

    www.thieme-connect.de/ejournals/toc/plantamedica