Planta Med 2010; 76(5): 461-464
DOI: 10.1055/s-0029-1186194
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Terpene Glycosides and Cytotoxic Constituents from the Seeds of Amomum xanthioides

Ki Hyun Kim1 , Jung Wook Choi1 , Sang Un Choi2 , Kang Ro Lee1
  • 1Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea
  • 2Korea Research Institute of Chemical Technology, Daejeon, Korea
Further Information

Publication History

received July 23, 2009 revised September 14, 2009

accepted September 16, 2009

Publication Date:
14 October 2009 (online)

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Abstract

Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1S,4S,5S)-5-exo-hydroxycamphor 5-O-β-D-glucopyranoside (2) and (1R,4R,5S)-5-endo-hydroxycamphor 5-O-β-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1S,4R,6R)-(+)-6-endo-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.