Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1S,4S,5S)-5-exo-hydroxycamphor 5-O-β-D-glucopyranoside (2) and (1R,4R,5S)-5-endo-hydroxycamphor 5-O-β-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1S,4R,6R)-(+)-6-endo-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.
3
Zhang S, Lan Y, Qin X.
Gas chromatography analysis of the volatile oil of the imported amomi semen (Amomum xanthioides Wall ex Bak.) and adulterants (Hong Ke Sha, Cao Dou Kou, Hong Dou Kou, and Zhu Mu Sha).
Yaowu Fenxi Zazhi.
1989;
9
219-222
5
Morikawa T, Matsuda H, Sakamoto Y, Ueda K, Yoshikawa M.
New farnesane-type sesquiterpenes, hedychiols A and B 8,9-diacetate, and inhibitors of degranulation in RBL-2H3 cells from the rhizome of Hedychium coronarium.
Chem Pharm Bull.
2002;
50
1045-1049
6
Maqua M P, Vines A C G, Caballero E, Grande M C, Medarde M, Bellido I S.
Components from Santolina rosmarinifolia, subspecies Rosmarinifolia and Canescens.
Phytochemistry.
1988;
27
3664-3667
8
Asakawa Y.
Chemical constituents of Alnus firma (Bebulaceae). I. Phenyl propane derivatives isolated from Alnus firma.
Bull Chem Soc Jpn.
1970;
43
2223-2229
9
Suga T, Ohta S, Aoki T, Hirata T.
An X-ray crystallographic study on the absolute configuration of dihydroyashabushiketol and the solvent-dependence of its optical rotation.
Bull Chem Soc Jpn.
1983;
56
3353-3357
12
Haddad M, Miyamoto T, Laurens V, Lacaille-Dubois M A.
Two new biologically active triterpenoidal saponins acylated with salicylic acid from Albizia adianthifolia.
J Nat Prod.
2003;
66
372-377
13
Miyazawa M, Miyamoto Y.
Biotransformation of (1R)-(+)- and (1S)-(−)-camphor by the larvae of common cutworm (Spodoptera litura).
J Mol Catal B Enzym.
2004;
27
83-89