An Efficient, One-Pot, Multicomponent Synthesis of β-Acetamido Carbonyl Compounds Using Cyanuric Chloride in an Aqueous Medium [¹]

Abstract

A one-pot, three-component reaction between an aromatic aldehyde, an enolizable ketone or a β-keto ester, and a nitrile in the presence of acetyl chloride is accomplished efficiently using cyanuric chloride in an aqueous medium to give the corresponding β-acetamido ketone or ester in high yield.

Key words

β-acetamido ketone - multicomponent reaction - cyanuric chloride - aqueous medium

1

Part 198 in the series ‘Studies on novel synthetic methodologies’.

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1

Part 198 in the series ‘Studies on novel synthetic methodologies’.