Preparation of Substituted Oxazoles by Ritter Reactions of α-Oxo Tosylates

Abstract

The Lewis acid catalyzed Ritter reaction of α-oxo tosylates with nitriles forms the basis of an efficient synthesis of oxazoles. Oxazoles with various substituents can be readily prepared from inexpensive starting materials.

Key words

heterocycles - cyclizations - nitriles - carbocations - oxazoles - Ritter reaction

References

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