An Efficient New Method for the Synthesis of Polysubstituted Pyrroles [¹]

Abstract

The three-component reactions of phenacyl bromide or its derivatives, amine, and dialkyl acetylenedicarboxylate in the presence of iron(III) chloride as a catalyst at room temperature afforded polysubstituted pyrroles in high yields.

Key words

polysubstituted pyrroles - three-component reaction - iron(III) chloride

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Part 283 in the series ‘Studies on Novel Synthetic Methodologies’.

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1

Part 283 in the series ‘Studies on Novel Synthetic Methodologies’.