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Synthesis 2010(12): 2085-2091
DOI: 10.1055/s-0029-1218734
DOI: 10.1055/s-0029-1218734
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Novel Palladium-Catalyzed Cross-Coupling of Thiomethylated Alkynes with Functionalized Organozinc Reagents
Further Information
Received
20 February 2010
Publication Date:
12 April 2010 (online)
Publication History
Publication Date:
12 April 2010 (online)
Abstract
A range of methylthio-substituted acetylenes undergo smooth palladium-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, and alkylzinc reagents using the Pd(OAc)2/DPE-Phos catalytic system at 25 or 50 ˚C without the need for copper salts.
Key words
alkynes - cross-coupling - organometallic reagents - palladium - zinc
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