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Synthesis 2010(11): 1860-1864
DOI: 10.1055/s-0029-1218736
DOI: 10.1055/s-0029-1218736
SPECIALTOPIC
© Georg Thieme Verlag
Stuttgart ˙ New YorkOrganocatalytic Highly Enantioselective Mannich-Type Reactions of Fluoromalonate with N-Boc-Aldimines
Further Information
Received
28 February 2010
Publication Date:
12 April 2010 (online)
Publication History
Publication Date:
12 April 2010 (online)
Abstract
The catalytic enantioselective Mannich reaction promoted by chiral bifunctional organocatalysts is described. The treatment of diethyl fluoromalonate with N-Boc-aldimines under mild reaction conditions afforded the corresponding β-amino-β-fluoromalonates with excellent enantioselectivity (93-97% ee).
Key words
Mannich reaction - asymmetric catalysis - bifunctional organocatalyst - fluoromalonate - aldimines
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