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Synthesis 2010(15): 2512-2514
DOI: 10.1055/s-0029-1218823
DOI: 10.1055/s-0029-1218823
SHORTPAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Short and Efficient Synthesis of (S)-(+)-2-(Hydroxymethyl)-6-piperidin-2-one
Further Information
Received
1 April 2010
Publication Date:
18 June 2010 (online)
Publication History
Publication Date:
18 June 2010 (online)
Abstract
A concise synthesis of (S)-(+)-2-(hydroxymethyl)-6-piperidin-2-one is described that employs l-aspartic acid as chiral pool starting material and Wittig reaction as the key step.
Key words
Wittig reaction - amino acid - piperidone - l-aspartic acid - hydrogenation - pipecolate
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