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Planta Med 2010; 76(6): 626-629
DOI: 10.1055/s-0029-1240595
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Antioxidative and Hepatoprotective Diarylheptanoids from the Bark of Alnus japonica

Nguyen Huu Tung1 , Sang Kyum Kim1 , Jeong Chan Ra2 , Yu-Zhe Zhao3 , Dong Hwan Sohn3 , Young Ho Kim1
  • 1College of Pharmacy, Chungnam National University, Daejeon, Korea
  • 2RNL BIO Co. Ltd., Nakseongdae-Dong, Gwanak-Gu, Seoul, Korea
  • 3Institute of Pharmaceutical Research Development, Department of Pharmacy, Wonkwang University, Iksan, Korea
Further Information

Publication History

received July 5, 2009 revised September 29, 2009

accepted October 15, 2009

Publication Date:
16 November 2009 (online)

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Abstract

The present study to evaluate the potential of constituents of the bark of Alnus japonica as a functional food with medicinal properties led to the identification of one new diarylheptanoid, named alusenone (1a), and 11 known ones (1b and 2–11). Their antioxidative and hepatoprotective activities were accessed by, respectively, a TOSC assay and a tBH-induced hepatotoxicity rat model. Mixtures 1, 2–6, 10, and 11 showed good antioxidative and hepatoprotective effects as compared with the positive controls.

Key words

Alnus japonica - Betulaceae - diarylheptanoid - alusenone - antioxidative activity - hepatoprotective activity

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Ph.D. Young Ho Kim

College of Pharmacy
Chungnam National University

305–764 Daejeon

Korea

Phone: + 82 4 28 21 59 33

Fax: + 82 4 28 23 65 66

Email: yhk@cnu.ac.kr

    www.thieme-connect.de/ejournals/toc/plantamedica