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Planta Med 2010; 76(14): 1587-1591
DOI: 10.1055/s-0030-1249810
Pharmacology
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model

Xiu-Wei Yang1 , Xin Huang1 , Lian Ma1 , Qi Wu1 , Wei Xu1
  • 1State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China
Further Information

Publication History

received Sept. 21, 2009 revised March 14, 2010

accepted March 16, 2010

Publication Date:
13 April 2010 (online)

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Abstract

The intestinal permeability and transport of 10 neolignans isolated from Myristica fragrans were studied by using the Caco-2 cell monolayer model. The 10 neolignans were measured by HPLC. Transport parameters and permeability coefficients were then calculated and compared with those of the model compounds, propranolol and atenolol. Among the 10 neolignans, the 8-O-4′-type neolignans demonstrated high permeability while the benzofuran-type neolignans were of poor to moderate permeability. Among them, eight neolignans were transported mainly via passive diffusion. These findings indicate that the 8-O-4′-type neolignans are well-absorbed compounds and can be used as oral leading compounds in drug discovery.

Key words

Myristicaceae - Myristica fragrans - neolignans - intestinal permeability - Caco‐2 cell monolayer

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Prof. Dr. Xiu-Wei Yang

State Key Laboratory of Natural and Biomimetic Drugs
School of Pharmaceutical Sciences
Peking University

38 Xueyuan Road

Haidian District

100191 Beijing

China

Phone: + 86 10 82 80 51 06

Fax: + 86 10 82 80 27 24

Email: xwyang@bjmu.edu.cn