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Planta Med 2011; 77(1): 60-65
DOI: 10.1055/s-0030-1250094
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antitubercular Resorcinol Analogs and Benzenoid C-Glucoside from the Roots of Ardisia cornudentata

Chun-Po Chang1 , Hsun-Shuo Chang1 , Chien-Fang Peng2 , Shiow-Ju Lee3 , Ih-Sheng Chen1
  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
  • 2Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical , University, Kaohsiung, Taiwan
  • 3Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan
Further Information

Publication History

received January 30, 2010 revised May 19, 2010

accepted June 8, 2010

Publication Date:
06 July 2010 (online)

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Abstract

Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1′-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4–6, 9–15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37RV in vitro, with MIC values of 2.5–60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone (8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC50 values of 2.3, 2.5 µg/mL).

Key words

Ardisia cornudentata - Myrsinaceae - resorcinol - benzenoid C‐glucoside - antitubercular activities - cytotoxicity

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Prof. Dr. Ih-Sheng Chen

Graduate Institute of Natural Products
College of Pharmacy
Kaohsiung Medical University

100 Shih-Chuan 1st Road

807 Kaohsiung

Taiwan

Phone: + 88 6 73 12 11 01 ext. 21 91

Fax: + 88 6 73 21 06 83

Email: m635013@kmu.edu.tw

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