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DOI: 10.1055/s-0030-1250094
© Georg Thieme Verlag KG Stuttgart · New York
Antitubercular Resorcinol Analogs and Benzenoid C-Glucoside from the Roots of Ardisia cornudentata
Publication History
received January 30, 2010
revised May 19, 2010
accepted June 8, 2010
Publication Date:
06 July 2010 (online)

Abstract
Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1′-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4–6, 9–15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37RV in vitro, with MIC values of 2.5–60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone (8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC50 values of 2.3, 2.5 µg/mL).
Key words
Ardisia cornudentata - Myrsinaceae - resorcinol - benzenoid C‐glucoside - antitubercular activities - cytotoxicity
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