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Planta Med 2011; 77(1): 66-69
DOI: 10.1055/s-0030-1250122
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Two New Lignans from the Roots of Pulsatilla koreana

To Dao Cuong1 , Tran Manh Hung1 , Jin-Cheol Kim2 , Jung-Im Huh2 , Seung Jun Kwack3 , Tae Suk Kang3 , Jung Hee Kim4 , Han Su Jang5 , Jae Sue Choi6 , Hyeong-Kyu Lee4 , KiHwan Bae7 , Byung Sun Min1
  • 1College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea
  • 2Korea Research Institute of Chemical Technology, Daejon, Korea
  • 3National Institute of Toxicological Research, Seoul, Korea
  • 4Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
  • 5Gyeongbuk Institute for Bio Industry, Gyeongbuk, Korea
  • 6Faculty of Food Science and Biotechnology, Pukyung National University, Busan, Korea
  • 7College of Pharmacy, Chungnam National University, Daejeon, Korea
Further Information

Publication History

received April 26, 2010 revised June 8, 2010

accepted June 12, 2010

Publication Date:
19 July 2010 (online)

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Abstract

Two new lignans, (2R,3R)-2β-(4′′-hydroxy-3′′-methoxybenzyl)-3α-(4′-hydroxy-3′-methoxybenzyl)-γ-butyrolactone 2-O-(β-D-glucopyranoside) (1) and (1S,2R,3S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3′,4′-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3–11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC50 value of 75.9 µM, compounds 8 and 9 had moderate effects with IC50 values of 182.2 and 166.5 µM, respectively.

Key words

Pulsatilla koreana - Ranunculaceae - lignan - anticomplement activity

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Prof. KiHwan Bae

College of Pharmacy
Chungnam National University

305-764 Daejeon

Korea

Phone: +82 4 28 21 59 25

Fax: +82 4 28 23 65 66

Email: baekh@cnu.ac.kr

Prof. Byung Sun Min

College of Pharmacy
Catholic University of Daegu

330 Geumnak 1-ri

712-702 Gyeongbuk

Korea

Phone: +82 5 38 50 36 13

Fax: +82 5 38 50 36 02

Email: bsmin@cu.ac.kr