Friedel-Crafts Reactions of 2-Naphthol with α-Amido Sulfones and Conversion of the Products with Nucleophiles [¹]

Abstract

2-Naphthol underwent Friedel-Crafts reaction with N-benzyloxycarbonylamino sulfones in the presence of InCl₃ at room temperature to form the corresponding sulfonyl derivatives in high yields. The products were subsequently reacted with nucleophiles such as allyltributyltin and anisole to replace the sulfonyl group.

Key words

2-naphthol - α-amido sulfone - InCl₃ - Friedel-Crafts reaction - nucleophile

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Part 209 in the series ‘Studies on Novel Synthetic Methodologies’.

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1

Part 209 in the series ‘Studies on Novel Synthetic Methodologies’.