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Synthesis 2010(23): 4082-4086
DOI: 10.1055/s-0030-1258300
DOI: 10.1055/s-0030-1258300
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
An Efficient Three-Component Synthesis of 3-(5-Alkyl/aryl-1,3,4-oxadiazol-2-yl)-3-hydroxy-1,3-dihydro-2H-indol-2-ones
Further Information
Received
26 August 2010
Publication Date:
14 October 2010 (online)
Publication History
Publication Date:
14 October 2010 (online)
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Abstract
An efficient three-component synthesis of 3-(1,3,4-oxadiazol-2-yl)-3-hydroxy-1,3-dihydro-2H-indol-2-ones is described. A mixture of N-isocyaniminotriphenylphosphorane, an isatin, and a carboxylic acid undergoes a 1:1:1 addition reaction under mild conditions to afford the title compounds in excellent yields.
Key words
N-isocyaniminotriphenylphosphorane - isatins - carboxylic acids - 1,3,4-oxadiazoles - multi-component reactions - heterocycles - cyclizations
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1a
Multicomponent Reactions
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