Synthesis of New Dihydropyrimido[4,5-b]quinolinetrione Derivatives Using a Four-Component Coupling Reaction

Abstract

A convenient and one-pot method for the efficient synthesis of the novel 8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trione derivatives via a four-component condensation reaction of aldehydes, amines, dimedone, and barbituric acid in the presence of tungestophosphoric acid (H₃PW₁₂O₄₀) as catalyst is described. This new approach proceeded smoothly in good to excellent yields and the pure products are separated from the reaction mixture by simple filtration.

Key words

multicomponent reaction - pyrimidine - dihydropyridine - barbituric acid - dimedone

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