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Synlett 2010(19): 2857-2860
DOI: 10.1055/s-0030-1259033
DOI: 10.1055/s-0030-1259033
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel and Efficient Synthesis of Unsymmetrical Trisulfides
Further Information
Received
9 August 2010
Publication Date:
10 November 2010 (online)
Publication History
Publication Date:
10 November 2010 (online)
Abstract
We have developed a convenient method for the synthesis of unsymmetrical trisulfides under mild conditions in very good yields. The designed method is based on the straightforward preparation of 1-[(5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)trisulfanyl]dodecane from readily available 5,5-dimethyl-2-sulfanyl-2-thioxo-1,3,2-dioxaphosphorinane, sulfur dichloride (SCl2) and dodecane-1-thiol. The unsymmetrical trisulfides can be obtained from aliphatic, aromatic thiols and l-cysteine derivatives as well.
Key words
unsymmetrical trisulfides - sulfur dichloride - thiols - l-cysteine - phosphorodithioic acid
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