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Synthesis 2011(12): 1847-1852
DOI: 10.1055/s-0030-1260463
DOI: 10.1055/s-0030-1260463
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Conjugate Additions of Acetylacetone to 3-Ylideneoxindoles: A Direct Access to Highly Enantioenriched Oxindole Derivatives
Further Information
Received
15 March 2011
Publication Date:
13 May 2011 (online)
Publication History
Publication Date:
13 May 2011 (online)
Abstract
A highly enantioselective organocatalytic conjugate addition of acetylacetone to 3-ylideneoxindoles is described. This method provides polysubstituted oxindoles in good to excellent enantioselectivities and high isolated yields.
Key words
organocatalysis - bifunctional activation - oxindole - conjugate addition - 3-ylideneoxindole
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