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Horm Metab Res 2011; 43(5): 297-299
DOI: 10.1055/s-0031-1273762
Hypothesis

© Georg Thieme Verlag KG Stuttgart · New York

Underexpression of C-myc in Adrenocortical Cancer: A Major Pathogenic Event?

P. M. Szabó1 , K. Rácz1 , P. Igaz1
  • 12ndDepartment of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
Further Information

Publication History

received 04.11.2011

accepted 21.02.2011

Publication Date:
16 March 2011 (online)

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Abstract

The protooncogene c-myc is a major factor in tumourigenesis. Whereas c-myc overexpression is considered to be a general feature of many tumours, we have recently demonstrated c-myc underexpression in adrenocortical cancer by a meta-analysis. We hypothesise that c-myc underexpression might be a central event in adrenortical tumourigenesis based on network topology modelling and previous experimental observations. In this brief hypothesis, we present our arguments and their possible relevance.

Key words

adrenal - tumour - meta-analysis - network

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Correspondence

Dr. P. IgazMD, MSc, PhD 

2nd Department of Medicine

Faculty of Medicine

Semmelweis University

Szentkiralyi street 46

1088 Budapest

Hungary

Phone: +36/1/4591 500

Fax: +36/1/2660 816

Email: igapet@bel2.sote.hu