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Synthesis 2011(23): 3767-3783  
DOI: 10.1055/s-0031-1289295
REVIEW
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 1,2,3-Triazole-Fused Heterocycles via Intramolecular Azide-Alkyne Cycloaddition Reactions

Krishna C. Majumdar*, Krishanu Ray
Department of Chemistry, University of Kalyani, Kalyani 741235, W.B., India
Fax: +91(33)25828282; e-Mail: kcm_ku@yahoo.co.in;
Further Information

Publication History

Received 14 April 2011
Publication Date:
19 October 2011 (online)

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Abstract

This brief review article describes the progress made in the synthesis of 1,2,3-triazole-fused heterocycles, over the last ten years, mainly by azide-alkyne cycloaddition reactions. In this article, the emphasis is on the various aspects of 1,3-dipolar cycloaddition reactions, especially intramolecular azide-alkyne dipolar cycloaddition reactions.

1 Introduction

2 Synthesis of Fused Triazoles

2.1 Synthesis of 1,2,3-Triazole-Fused Heterocycles by Huisgen (Thermal) 1,3-Cycloaddition Reactions

2.2 Microwave-Assisted 1,3-Dipolar Cycloaddition Reactions for the Synthesis of Condensed Triazoles

2.3 Copper-Catalyzed Cycloaddition Reactions for the Synthesis of Condensed Triazoles

2.4 Copper/Other-Metal-Catalyzed Cycloaddition Reactions for the Synthesis of Condensed Triazoles

2.5 Synthesis of Triazole-Containing Macrocycles by Azide-Alkyne 1,3-Dipolar Cycloaddition Reactions

3 Conclusion

Key words

1,2,3-triazole - azide - alkyne - cycloaddition - heterocycles

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1

Present address: Department of Chemical Sciences, Tezpur University, Napaam, Tezpur 784 028, Assam, India.