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Synthesis 2011(24): 3997-4002
DOI: 10.1055/s-0031-1289592
DOI: 10.1055/s-0031-1289592
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkOne-Pot Synthesis of Isocyanides from Alcohols
Weitere Informationen
Received
30 August 2011
Publikationsdatum:
04. November 2011 (online)
Publikationsverlauf
Publikationsdatum:
04. November 2011 (online)

Abstract
A one-pot reaction of alcohols with trimethylsilyl cyanide and methanesulfonic acid with subsequent neutralization by triethylamine and dehydration by tosyl chloride and pyridine gave the corresponding isocyanides in moderate-to-high yields. This method was used to synthesize tertiary and benzylic isocyanides from the corresponding alcohols.
Key words
isocyanides - alcohols - Ritter reactions
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