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Synthesis 2012(2): 215-218
DOI: 10.1055/s-0031-1289644
DOI: 10.1055/s-0031-1289644
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Parallel Synthesis of Aminobenzimidazole-Tethered Thiazoles
Further Information
Received
13 October 2011
Publication Date:
15 December 2011 (online)
Publication History
Publication Date:
15 December 2011 (online)
Abstract
A multistep approach to construct thiazole-derived aminobenzimidazoles from commercially available amino acids, amines, carboxylic acids, and α-halo ketones is described. Coupling of 9-fluorenylmethoxycarbonyl-protected (Fmoc-protected) amino acids to resin-bound aminobenzimidazoles provides essential intermediates for the construction of an array of thiazoles by utilizing the Hantzsch cyclization strategy. The aminobenzimidazole-tethered thiazoles were isolated in moderate yields.
Key words
solid-phase synthesis - aminobenzimidazoles - amino acids - thiazoles - heterocycles - Hantzsch cyclization
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