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Synthesis 2012(5): 677-685  
DOI: 10.1055/s-0031-1289697
REVIEW
© Georg Thieme Verlag Stuttgart ˙ New York

Transition-Metal-Catalyzed Synthesis of Aromatic Ketones via Direct C-H Bond Activation

Changduo Pana, Xiaofei Jiab, Jiang Cheng*b
a Wenzhou Institute of Industry & Science, Wenzhou 325000, P. R. of China
b College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325000, P. R. of China
Fax: +86)(577)56998939; e-Mail: jiangcheng@wzu.edu.cn;
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Publication History

Received 2 November 2011
Publication Date:
13 February 2012 (online)

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Abstract

There are several alternative methods to Friedel-Crafts acylation for the synthesis of ketones. Among these methods, transition-metal-catalyzed acylation of arenes via C-H bond cleavage represents a direct and promising approach to access ketones, in view of the advantages of C-H bond activation; recent advances in the development of this area are summarized.

1 Introduction

2 Acylation of sp² C-H Bonds with Aldehydes via C-H Bond Cleavage

3 Acylation of Arenes with α-Oxocarboxylic Acids via Decarboxylation and C-H Bond Cleavage

4 Acylation of sp² C-H Bonds with α,β-Unsaturated Carboxylic Acids

5 Acylation of sp² C-H Bonds with Acyl Chlorides

6 Summary

Key words

acylation - transition metals - arenes - ketones - C-H bond functionalization