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Synthesis 2012; 44(12): 1798-1805
DOI: 10.1055/s-0031-1290775
DOI: 10.1055/s-0031-1290775
special topic
Synthesis of N-Alkyl-Substituted 4-Quinolones via Tandem Alkenyl and Aryl C–N Bond Formation
Further Information
Publication History
Received: 04 January 2012
Accepted: 01 March 2012
Publication Date:
03 April 2012 (online)
Abstract
N-Alkyl-substituted 4-quinolones are present as the key structural motif in many marketed drugs. An efficient one-step tandem amination approach was developed to afford N-alkyl-substituted 4-quinolones in high yields from easily accessible o-chloroaryl acetylenic ketones and functionalized alkyl amines. The approach complements and extends our previous work. Compared with other reported methods, the current method provides a very simple and convenient route.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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