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Synthesis 2012; 44(9): 1339-1342
DOI: 10.1055/s-0031-1290812
DOI: 10.1055/s-0031-1290812
paper
A Concise Synthesis of 6H-Indolo[2,3-b]quinolines: Formal Synthesis of Neocryptolepine
Further Information
Publication History
Received: 07 February 2012
Accepted after revision: 02 March 2012
Publication Date:
05 April 2012 (online)
Abstract
A new two-step approach for the synthesis of 6H-indolo[2,3-b]quinolines is described using indole C3 alkylation and a one-pot reduction–cyclization–aromatization sequence. The synthesis of the parent 6H-indolo[2,3-b]quinoline system constitutes a formal synthesis of the alkaloid neocryptolepine (cryptotackieine).
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