Synthesis of 3-Substituted Isocoumarin Derivatives via CuI-Catalyzed Reaction of o-Bromobenzamides with 1,3-Diketones

Abstract

An approach to a variety of 3-substituted isocoumarins has been developed. The reaction proceeded from o-bromobenz­amide derivatives and 1,3-diketones via CuI-catalyzed reaction in DMF under the action of K₃PO₄ at 120 °C without ligands or additives.

Key words

copper - domino reaction - isocoumarins - o-bromobenz­amides - 1,3-diketones

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